Gastrokinetic and Gastroprotective Activity of Gasex

Mohd.Azeemuddin Mukhram, Suryakant D Anturlikar, Mohamed Rafiq, Pralhad Sadashiv Patki, Paramesh Rangesh


Present study was aimed to evaluate the gastrokinetic and gastroprotective effect of Gasex a polyherbal formulation in experimental models of phenol red test meal method for gastrokinetic activity and acid-induced gastrointestinal lesions for gastroprotective activity. Gasex at a dose of 500 and 1000 mg/kg showed statistically significant gastrokinetic activity by increasing the percentage of gastric emptying and small intestinal transit, the higher dose of Gasex was comparable to the reference standard Domeperidone (10 mg/kg). The higher dose of Gasex (1000 mg/kg) showed gastroprotective activity by significantly decreasing the gastric volume and mean gastric lesion score and the same was reflected in histopathological findings. The present finding highlights few of the underlying modes of action of Gasex in the successful management of various gastrointestinal conditions.


Gasex, Phenol red, HCl, gastrokinetic , gastroprotective, histopathology.

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McPhee, Stephen J, Papadakis, Maxine A, Tierney, Lawrence M. Current medical diagnosis and treatment: Alimentary tract.46th Edition; McGraw-Hill. 2007: 549-554. (

Henry P. Parkman, John A Bonino. Pharmacological management of chronic gastroparesis. Practical gastroenterology. June 2007:45-59. (

Henry P Parkman, Richard W Mccallum. Gastroparesis: Pathophysiology, presentation and treatment.Springer science; Humana press; Newyork.2012: 80-81.

Charaka Samhita. Shri Gulabkunverba Ayurvedic Society, Jamnagar, Ayurvedic Mundranalaya, Jamnagar, 1949; Vol. (IV): 1952-2032.

Tamhane MD, Thorat SP, Rege NN, Dahanukar SA. Effect of oral administration of Terminalia chebula on gastric emptying: an experimental study. J Postgrad Med 1997; 43: 12-13. (

Barquist E, Bonaz B, Martinez V, Rivier J, Zinner MJ, Taché Y. Neuronal pathways involved in abdominal surgery-induced gastric ileus in rats. Am J Physiol. 1996 ;April 270(4):888-94 (

AD Suchitra, SA Dkhar, DG Shewade, CH Shashindran. Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice. World J Gastroenterol 2003; 9(4):779-783. (

Martin E Edelsbrunner, Motoko Nakano and Peter Holzer. Afferent signaling from the acid-challenged rat stomach is inhibited and gastric acid elimination is enhanced by lafutidine. BMC Gastroenterology. 2009; 9:40.

Sadiq Yusuf , Abdulkarim Agunub, Mshelia Diana .The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. Journal of Ethnopharmacology. 2004; 93:33–37.

Smout AJPM, Akkermans LMA. Stomach, pylorus and proximal duodenum. In: Normal and disturbed motility of the gastrointestinal tract. Petersfield, UK: Wrightson Biomedical Publishing Ltd. 1992:87-114.

Heikkinen M, Pikkarainen P, Takala J, Rasanen H, Julkunen R. Etiology of dyspepsia: four hundred unselected consecutive patients in general practice. Scand J Gastroenterol.1995; 6:519-523Parkman H. P, Camilleri M, Farrugia G, Mccallum R W, Bharucha AE, Mayer EA,Tack JF, Spiller R, etal . Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting Neurogastroenterol Motil.2010; 22:113–133

Tack J, Lee KJ. Pathophysiology and treatment of functional dyspepsia. J Clin

Gastroenterol.2005; 39:211-216

Kong MF, Horowitz M, Jones KL, Wishart JM, Harding PE. Natural history of diabeticgastroparesis. Diabetes Care. 1999;22:503-507

Jones KL, Russo A, Stevens JE, Wishart JM, Berry MK, Horowitz M. Predictors of delayed gastric emptying in diabetes. Diabetes Care. 2001; 24:1264-1269.

De Block CEM, De Leeuw IH, Pelckmans PA, Callens D, Máday E, Van Gaal LF. Delayed gastric emptying and autoimmunity in type I diabetes. Diabetes Care.

; 25:912-917.

Strid H, Simrén M, Stotzer PO, Abrahamsson H, Bjornsson ES. Delay in gastric emptying in patients with chronic renal failure. Scand J Gastroenterol. 2004; 39:516-520.

Parkman H. P., Camilleri M, Farrugia G, Mccallum R W, Bharucha AE,. Mayer EA, Tack JF, Spiller R, etal . Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting Neurogastroenterol Motil (2010) 22, 113–133.

Trial of Gasex in Functional Dyspepsia. Probe.1981; XX(3):208.

Shekar Kumar MG, Prasad SR and Mitra SK. Evaluation of efficacy and safety of Gasex syrup in functional dyspepsia. Indian Journal of Clinical Practice.2007; 18 (6):29-34.

Inder Singh, Ranbir Singh .Trial of Gasex and Herbolax for Preparation of Patients before radiological examination. Indian Medical Journal.1986; 6 (80): 87-88.

Brogden RN, Carmine AA, Heel RC et al: Domperidone: a review of its pharmacological activity,pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an anti-emetic. Drugs 1982; 24: 360-400

Riyad A, McCallum RW: Metoclopramide: pharmacology and clinical application. Ann Intern Med. 1983; 98: 86-95

Reyntjens AJ: Clinical pharmacology and therapeutics of domperidone. Clin Res Rev. 1983; 3: 91-100.

Broekaert A: Effect of domperidone on gastric emptying and secretion. Postgrad Medj 1979; 55 (suppl 1): 11-14

Jacobs F, Akkermans LMA, Hongeo 0 et al: Effects of domperidone on gastric emptying of semi-solid and solid food. In Towse G (ed): Progress with domperidone, a gastrokinetic and anti-emetic agent. R Soc Med London. 1981: 11-20.

Baeyens R, Van De Velde E, De Schepper A et al: Effects of intravenous and oral domperidone on the motor function of the stomach and small intestine. Ibid: 19-23

Mohd. Ali,Palaniyamma. D. Gastroprotection with Gasex tablets in GI disorders and preradiographic preparation: A meta-analysis. Indian Journal of Clinical Practice. January 2011. 21(8): 427-432Collings KL, et al. Aliment Pharmacol Ther 2002;16(12):2029-35.


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