Aloe-emodin novel anticancer Herbal Drug

Khemkaran Ahirwar, Sanmati K. Jain


The electrochemical behaviour of the anticancer herbal drug emodin hydroxyanthraquinone present in Aloe vera leaves has a specific in vitro and in vivo antineuroectodermal tumor activity. The compound does not inhibit the proliferation of normal fibroblasts n or that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of the induction of apoptosis, whereas the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. Natural compounds that have traditionally been used to treat a variety of diseases for hundreds of years (1, 2, 3) . We assayed only those natural compounds that have already been proven to be nontoxic, and we evaluated their efficacy against highly malignant tumors that are not normally included in the classical screening assays.

Keywords: Anticancer herbal drug; Emodin; Electrochemical; Dynamics parameters.

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Cassady JM and Douros JD. Anticancer agents based on natural product models. New York: Academic Press, 1980.

Cragg GM. Role of plants in the National Cancer Institute Drug Discovery and Development Program Kinghorn AD, Balandrin MF. eds. Human Medicinal Agents from Plants: 80-95, American Chemical Society Books Washington, DC 1993.

Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 1991;139:271-279.

Ricotti E, Fagioli F, Garelli E, Linari C, Crescenzio N, Horenstein AL, Pistamiglio P, Vai S, Berger M, Cordero di Montezemolo L, Madon E, Basso G. c-kit is expressed in soft tissue sarcoma of neuroectodermic origin and its ligand prevents apoptosis of neoplastic cells. Blood. 1998;91:2397-2405.

Diaspro A, Corosu M, Ramoino P, Robello M. Two-photon excitation imaging based on a compact scanning head. IEEE Eng. Med. Biol. 1999;18:18-22.

Ciman M, Rascio N, Pozza D, Sartorelli L. Synaptosome-free rat brain mitochondrial preparation: an improved method. Neurosc. Res. Commun. 1992;11:87-92.

Hazlehurst LA, Foley NE, Gleason-Guzman MC, Hacker MP, Cress AE, Greenberger LW, De Jong MC, Dalton WS. Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line. Cancer Res. 1999;59:1021-1028.

Palù G, Palumbo M, Antonello C, Meloni GA, Marciani-Magno S. A search for potential antitumor agents: biological effects and DNA binding of a series of anthraquinone derivatives. Mol. Pharmacol. 1985;29:211-217.

Zhang L, Chang CJ, Bacus SS, Hung MC. Suppressed transformation and induced differentiation of HER- 2/neu-overexpressing breast cancer cells by emodin. Cancer Res. 1995;55:3890.

Lee HZ, Hsu SL, Liu MC, Wu CH. Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. Eur J Pharmacol. 2001;431:287–295.

Yeh FT, Wu CH, Lee HZ. Int J Cancer 2003;106:26–33.

Kuo PL, Lin TC, Lin CC. The antiproliferative activity of aloe-emodin is through p53- dependent and p21- dependent apoptotic pathway in human hepatoma cell lines. Life Sci. 2002;71:1879–1892.

Chen HC, Hsieh WT, Chang WC, Chung JG. Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. Food Chem Toxicol. 2004;42:1251– 1257.

Pecere T, GazzolaMV, Mucignat C, Parolin C,Vecchia FD, Cavaggioni A, Basso G, DiasprA, Salvato B, Carli M, Palu G. Aloe-emodin is a new type of anticancer agent withselectiveactivity against neuroectodermal tumors. Cancer Res. 2000;60:2800–2804.

Pecere T, Sarinella F, Salata C, Gatto B, Bet A, Dalla Vecchia F, Diaspro A, Carli M, Palumbo M, Palu G.Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin. Int J Cancer 2003;106:836–847.

Kuo PL, Hsu YL, Ng LT, Lin CC. Rhein inhibits the growth and induces theapoptosisofHepG2 cells. Planta Med. 2004;70:12–16.

Acevedo-Duncan M, Russell C, Patel S, Patel R. Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. Int Immunopharmacol. 2004;4:1775–1784.

Kamei H, Koide T, Kojima T, HashimotoY, Hasegawa M. Inhibition of cell growthinculturebyquinones. Cancer Biother Radiopharm. 1998;13:185.

Sanjeev Banerjee, Zhiwei Wang, Mussop Mohammad, Fazlul H. Sarkar, and Ramzi M. Mohammad. Efficacy of Selected Natural Products as Therapeutic Agents against Cancer. J. Nat. Prod. 2008;71:492–496.

Scho¨rkhuber M, Richter M, Dutter A, Sontag G and Marian B. Effect of anthraquinone-laxatives on the proliferation and urokinase secretion of normal premalignantand malignant colonic epithelial cells. Eur. J. Cancer. 1998;34:1091–1098


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