Antibacterial, Antioxidant activity and Phytochemical studies of Crossandra infundibuliformis leaf extracts

SHARMILA NARAYANAN, Gomathi Nagarajan

Abstract


The aim of the present study was to evaluate Crossandra infundibuliformis (Acanthaceae family) for its antibacterial, antioxidant activity and phytochemical constituents. The leaves of C. infundibuliformis were screened for antibacterial activity against six pathogenic bacteria isolated from clinical samples such as Shigella dysenteria, Pseudomonas aeruginosa, Serratia marcescens, Salmonella typhimurium, Proteus mirabilis & Staphylococcus aureus by extracting them in ethanol, petroleum ether and water. Ethanol extract exhibited inhibition zone against all the pathogens comparable to the standard (Amikacin), whereas no zone of inhibition was observed in petroleum ether and water extracts. Phytochemical analysis showed the presence of flavonoids, saponins, terpenoids, cardiac glycoside, reducing sugars and tannins. The ethanol extract of C. infundibuliformis leaves appeared to be good antioxidant agent with maximum inhibition percentage of 89.27 ±0.284 % at 16µg/ml whereas standard Quercetin showed maximum inhibition percentage of 94.30 ±0.272 % at 22µg/ml.

Full Text:

PDF

References


Shanmugam S, Gayathiri N, Sakthivel B, Ramar S, Rajendran K. Plants used as medicine by Paliyar tribes of Shenbagathope in Virudhunagar district of Tamil Nadu, India. Ethanobotanical leaflets. 2009;13:370-378.

Kumar SA, Sumalatha K, Lakshmi S. Aphrodisiac Activity of Crossandra infundibuliformis (L.) on Ethanol induced Testicular Toxicity in male rats. Pharmacologyonline. 2010;2:812-817.

Madumita G, Saral AM, Senthilkumar B, Sivaraj A. Hepatoprotective potential of petroleum ether leaf extract of Crossandra infundibuliformis on CCl4 induced liver toxicity in albino mice. Asian Pacific Journal of Tropical Medicine. 2010;3:788-790.

Priya SV, Saratha R. Crossandra infundibuliformis leaves as an effective inhibition for mild steel corrosive in 1M HCl [Abstract]. Ajrc, 2010;3:434.

Ayoola GA, Coker HAB, Adesegun SA, Adepoju-Bello AA, Obaweya K, Ezennia EC, Atangbaljila TO. Phytochemical screening and Antioxidant activities of some selected medicinal plants used for malaria therapy in Southwestern Nigeria. Tropical J of Pharmaceutical Research. 2008;7(3):1019-1024.

Blois MS. Antioxidant determinations by the use of a stable free radical. Nature. 1958;181:1199-1200.

Nmorsi OPG, Ukwandu NCD, Egwunyenga AO. Antioxidant status of Nigerian children with Plasmodium falciparum malaria. African J of Microbiology Research. 2007;5:61-64.

Tsuchiya H, Sato M, Miyazaki T, Fujuwara S, Tanigaki S, Ohayama M, Tanaka T, Linuma M. Comparative study on the antibacterial activities of phytochemical flavonones against methicillin resistant Staphylococcus aureus. J of Ethanopharmacology. 1996;50:27-34.

Ya C, Gaffney SH, Lilley TH, Haslam E. Carbohydrate-Polyphenol Complexation. In: Chemistry and Significane of condensed tannins. Hemingway RW, Karchesy JJ ed. In Plenum Press, New York. 1988;553.

Nabila B, Mirice S, Puran A. Antioxidant and Antimicrobial activities of Pistacia lentiscus and Pistacia attantica extract. Afri. J of Pharmacology. 2008;2(2):22-28.

Dewick PM. Medicinal Natural products: A Biosynthetic approach. 2nd ed: England. John Wiley and Sons ltd; 2002:p.241-243.

Rupasinghe HP, Jackson CJ, Poysa V, Beriado CD, Bewley JD, Jenkinson J. Soyasapogenol A and B distribution in soybean (Glycine max L. Merr) in relation to seed physiology, genetic variability and growing location. J of Agriculture and Food Chem. 2003;51:5888-5894.

Malairajan P, Gopalakrishnan G, Narasimhan S, Veni KJK. Analgesic activity of some Indian medicinal plants. J Ethnopharmacol. 2006; 106:425-8.

Argal A, Pathak AK. CNS activity of Calotropis gigantea roots. J. Ethanopharmacology. 2006;106.142-145.


Refbacks

  • There are currently no refbacks.
';



Copyright (c)

                AR Journals

Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India

              Copyright@arjournals.org (Design) 2009-2021

 

Follow @arjournals on Twitter