Anti-inflammatory and analgesic activities of Jateorhiza macrantha (Menispermaceae)

Glory Oluremilekun Ajayi, O.A. Salako, M.I Mosebolatan

Abstract


Jateorhiza macrantha (Hook.f.) Exell and Mendonça (Menispermaceae) is a common medicinal plant found in tropical Africa. Jateorhiza macrantha is used as an anti-hemorrhagic, to combat syphilis and headache. This study was performed to evaluate the analgesic and anti-inflammatory activities of its extract.

The analgesic activity of the methanolic extract of Jateorhiza macrantha was investigated using the acetic acid (chemical) and tail-clip (mechanical) models of nociception in mice and the anti-inflammatory activity was investigated using the carrageenan-induced paw oedema in rats.  In acetic acid-induced writhing test, the extract at doses 100, 200 and 400 mg/kg significantly (P < 0.05, 0.01) reduced the writhing reflex in a dose dependent manner. In the application of the metal artery clip unto the tail of animals, the extract caused a significant (P < 0.05) dose dependent increase in reaction latency with peak effect (7.0%) inhibition produced at the highest dose of 400 mg/kg. In the carrageenan induced paw oedema test, the extract produced a dose dependent significant (P < 0.05, 0.01, 0.001) inhibition of oedema.

The results obtained in this study lend credence to the ethnomedicinal use of the plant in the management of pain and inflammatory conditions.


Keywords


Jateorhiza macrantha, methanolic extract, analgesic and, anti-inflammatory activities

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