Evaluation of Hepatoprotective and In-Vivo Antioxidant Activity of Tamarindus indica L. Seeds Extracts in Streptozotocin Induced Diabetic Rats

Bibekananda Meher, Deepak Das

Abstract


Hydroalcoholic and aqueous extract of Tamarindus indica seeds was evaluated for hepatoprotective and antioxidant activity in Streptozotocin induced diabetic rats. Diabetes induced hepatic damage was evaluated by the serum markers such as SGOT, SGPT, ALP, Bilirubin. Further the effect of HAETIS and AETIS on oxidative stress was determined by the markers of oxidative stress: Lipid peroxidation (LPO), Determination of Super Oxide Dismutase (SOD), Determination of Catalase (CAT), glutathione (GSH) were estimated in liver tissue. HAETIS and AETIS at a dose level of  100 mg/kg and 200 mg/kg produce significant (P< 0.05) hepatoprotection by decreasing the activity of serum enzymes, biliribin and lipid perioxidation, while they significantly increase the level of Glutathione, Super Oxide Dismutase and catalase in a dose dependant manner. Histo-pathological studies supports the above finding results indicate that hydroalcoholic extracts of Tamarindus indica at 200 mg/kg showed more significant hepatic protection as compared to other extracts.

Keywords


Tamarindus indica, Streptozotocin, Diabetes, hepatoprotective effect, antioxidant

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