The influence of hot melt subcoat and Polymer coat combination on highly water soluble sustained release multiparticulate formulation

Ravindra Tiwari, RSR Murthy, Sunil Kumar Agarwal


The purpose of this study was to develop and optimize oral controlled-release formulations for highly water soluble model drug Venlafaxine hydrochlorid using a combination of hot-melt subcoating s based coating polymerand aqueous polymer coating. Hot melt subcoating was achieved by centrifugal granulator. For the polymer coating, Acrylate-based (Eudragit RS 30D and Eudragit NE 30D), were used. Furthermore polymer coating, the pellets were evaluated with respect to their ability to modulate the in-vitro release of a highly water soluble compound. By using hot melt subcoating, the polymer coating level of pellets was reduced by half to obtain sustained release profile. In this study, the release profile of pellets was found to be optimum at a 4% level of hot melt subcoating and 15 % level of Eudragit® NE30D polymer coating combination, consequently meeting the desired responses. The release profile of the pellets prepared by this technique satisfied the first order plot with (R sq =0.9434) indicating the release of water soluble drug from porous matrices. By means of this hot-melt subcoating and polymer coating combination, sustained-release pellets containing venlafaxine hydrochloride were successfully prepared.



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