VESICULAR DRUG DELIVERY SYSTEMS: A NOVEL APPROACH FOR DRUG TARGETING

Sunil Kamboj, Vipin Saini, Nancy Maggon, Suman Bala, Vikas Jhawat

Abstract


The objective of the study is to evaluate the potential of novel vesicular drug delivery systems for drug targeting. Novel vesicular drug delivery systems aim to deliver the drug at a rate directed by need of body during the period of treatment, and channel the active entity to the site of action. Vesicular drug delivery systems have been used to improve the therapeutic index, solubility, stability and rapid degradation of drug molecule. Thus a number of novel vesicular drug delivery systems have been developed that allow drug targeting and sustained or controlled release of drug. The focus of this review is to discuss various lipoidal and non-lipoidal vesicles with special emphasis on targeting of drugs.


Keywords


Vesicular drug delivery systems, drug targeting, bioavailability enhancement, lipoidal and non-lipoidal biocarriers.

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References


. Biju SS, Talegaonkar S, Mishra PR, Khar RK. Vesicular systems: an overview. Indian J Pharm Sci. 2006; 68(2):141-153.

. Manish G, Vimukta S. Targeted drug delivery system: a review. Res J Chem Sci. 2011; 1(2):135-138.

. Mujoriya R, Bodla RB, Dhamande K, Singh D, Patle L. Niosomal drug delivery system: the magic bullet. J Appl Pharm Sci. 2011; 01(09):20-23.

. Kumar R, Kumar S, Jha SS, Jha AK. Vesicular system-carrier for drug delivery. Der Pharmacia Sinica. 2011; 2(4):192-202.

. Kumar D, Sharma D, Singh G, Singh M, Rathore MS. Lipoidal soft hybrid biocarriers of supramolecular construction for drug delivery. Int Scholar Res Network Pharm. 2012; 2012:1-14.

. Anwekar H, Patel S, Singhai AK. Liposome-as drug carrier. Int J Pharm Life Sci. 2011; 2(7): 945-951.

. Wagner A, Uhl KV. Liposome technology for industrial purposes. J Drug Deliv. 2011; 2011:1-9.

. Samad A, Sultana Y, Aqil M. Liposomal systems: an update review. Curr Drug Deliv. 2007; 4:297-305.

. Sivasankar M, Katyayani T. Liposomes-the future of formulations. Int J Res Pharm Chem. 2011; 1(2):259-267.

. Storm G, Crommelin DJA. Liposomes: quo vadis. Pharm Sci Technol Today. 1988; 1(1):19-31.

. Kelly C, Jefferies C, Cryan SA. Targeted liposomal drug delivery to monocytes and macrophages. J Drug Deliv. 2011; 2011:1-11.

. Shao P, Wang B, Wang Y, Li J, Zhang Y. The application of thermosensitive nanocarriers in controlled drug delivery. J Nanomater. 2011; 2011:1-12.

. Lehtinen J, Raki M, Bergstrom KA, Uutela P, Lehtinem K, Hiltunen A, Pikkarainen J, Liang H, Pitkanen S, Maatta AM, Ketola RA, Yliperttula M, Wirth T, Urtti A. Pre-targeting and direct immunotargeting of liposomal drug carriers to ovarian carcinoma. Plosone. 2012; 7(7):1-10.

. Doijad RC, Bhambere DS, Manvi FV, Deshmukh NV. Formulation and characterization of vesicular drug delivery system for anti-HIV drug. J Global Pharm Technol. 2009; 1(1):94-100.

. Vyas SP, Khatri K, Goyal AK. Functionalized nanocarriers to image and target fungi infected cells. J Med Mycol. 2009, 47 (Suppl 1):s362-s368.

. Ochi A, Shibata S, Mori K, Sato T, Sunamoto J. Targeting chemotherapy of brain tumor using liposome encapsulated cisplatin. Part 2. Pullulan anchored liposomes to target brain tumor. J Drug Deliv.1990; 5:261-271.

. Bhatt DA, Pethe AM. Lipoidal technology-a promising drug delivery for poorly water soluble drugs. Int J Pharm Res Dev. 2010; 2(7):1-11.

. Gill V, Kumar MS, Khurana B, Arora D, Mahadevan N. Development of amphotericin B loaded modified emulsomes for visceral leishmaniasis: in vitro. Int J Recent Adv Pharm Res 2011; 2:14-20.

. Raza K, Katare OP, Setia A, Bhatia A, Singh B. Improved therapeutic performance of dithranol against psoriasis employing systematically optimized nanoemulsomes. J Microencapsul. 2012:1-12.

. Vyas SP, Subhedar R, Jain S. Development and characterization of emulsomes for sustained and targeted delivery of an antiviral agent to liver. J Pharm Pharmacol. 2006; 58:321-326.

. Vale CA, Corvo ML, Martins LCD, Marques CR, Storm G, Cruz MEM, Martins MBF. Construction of enzymosomes: optimization of coupling parameters. NSTI-Nanotech. 2006; 2: 396-397.

. Gaspar MM, Martins MB, Corvo ML, Cruz MEM. Design and characterization of enzymosomes with surface-exposed superoxide dismutase. Biochimica Biophysica Acta. 2003; 1609:211-217.

. Vijayakumar MR, Sathalia AH, Arun K. Formulation and evaluation of diclofenac potassium ethosomes. Int J Pharm Pharm Sci. 2010; 2(4):82-86.

. Gangwar S, Singh S, Garg G. Ethosomes: a novel tool for drug delivery through skin. J Pharm Res. 2010; 3(4):688-691.

. Nikalje AP, Tiwari S. Ethosomes: a novel tool for transdermal drug delivery. Int J Res Pharm Sci. 2012; 2(1):1-20.

. Bhalaria MK, Naik S, Misra AN. Ethosomes: a novel delivery system for antifungal drugs in the treatment of topical fungal diseases. Indian J Exp Biol. 2009; 47:368-375.

. Jain S, Tiwary AK, Sapra B, Jain NK. Formulation and evaluation of ethosomes for transdermal delivery of lamivudine. AAPS Pharm Sci Tech. 2007; 8(4):E1-E9.

. Presa PDL, Rueda T, Morales MDP, Chichon JF, Arranz R, Valpuesta JM, Hernando A. Gold nanoparticles generated in ethosome bilayers as revealed by cryo-electron-tomography. J Phy Chem B. 2009; 113:1-30.

. Lankaldapalli S, Damuluri M. Sphingosomes: applications in targeted drug delivery. Int J Pharm Chem Biol Sci. 2012; 2(4):507-516.

. Saraf S, Paliwal S, Saraf S. Sphingosomes a novel approach to vesicular drug delivery. Int J Curr Sci Res. 2011; 1(2):63-68.

. Malakar J, Gangopadhyay A, Nayak AK. Transferosome: an opportunistic carrier for transdermal drug delivery system. Int Res J Pharm. 2012; 3(3):35-38.

. Ambarish G, Prajapati SK, Anand JP, Akhtar A, Aviral. Ultradeformable vesicle as a novel drug delivery system. Int Res J Pharm. 2012; 3(8):116-120.

. Kaushik A, Dwivedi A, Sunda M. Transferosome: the drug loaded ultradeformable vesicles for transdermal drug delivery. Int Res J Pharm. 2011; 2(11):40-42.

. Prajapati ST, Patel CG, Patel CN. Transferosomes: a vesicular carrier system for transdermal drug delivery. Asian J Biochem Pharm Res. 2011; 1(2):507-524.

. Cevc G, Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable carriers, transferosomes. Biochimica et Biophysica Acta. 2001; 78137:1-15.

. Patel JL, Bharadia PD. A review on: pharmacosomes as a novel vesicular drug delivery system. World J Pharm Res. 2012; 1(3):456-469.

. Semalty A, Semalty M, Singh D, Rawat MSM. Development and physicochemical evaluation of pharmacosomes of diclofenac. Acta Pharm. 2009; 59:335-344.

. Kumar DP, Arnab De. Pharmacosomes: A potential vesicular drug delivery system. Int Res J Pharm. 2012; 3(3):102-105.

. Ping A, Yi guang J, Da wei C. Preparation and in vivo behavior of didanosine pharmacosomes in rats. Chin J Pharm. 2005; 3(4):227-235.

. Zhang ZR, Wang JX, Lu J. Optimization of the preparation of 3’,5’-dioctanoyl-5-fluoro-2’-deoxyuridine pharmacosomes using central composite design. Acta Pharmaceutica Sinica. 2001; 36(6):456-461.

. Namdeo A, Jain NK. Niosomes as drug Carriers. Indian J Pharm Sci. 1996; 58(2):41-46.

. Biswal S, Murthy PN, Sahu J, Sahoo P, Amir F. Vesicles of non-ionic surfactants (niosomes) and drug delivery potential. Int J Pharm Sci Nanotechnol. 2008; 1(1):1-8.

. Jadhav SM, Morey P, Karpe M, Kadam V. Novel vesicular system: an overview. J Appl Pharm Sci. 2012; 02(01):193-202.

. Khan A, Sharma PK, Visht S, Malviya R. Niosomes as colloidal drug delivery system: a review. J Chronother drug deliv. 2011; 2(1):15-21.

. Mahale NB, Thakkar PD, Mali RG, Walnuj DR, Chaudhari SR. Niosomes: novel sustained release nonionic stable vesicular systems-an overview. Adv Colloid Interfac Sci. 2012; 183-184:46-54.

. Rajera R, Nagpal K, Singh SK, Mishra DN. Niosomes: a controlled and novel drug delivery system. Biol. Pharm. Bull. 2011; 34(7): 945-953.

. Sankhyan A, Pawar P. Recent trends in niosomes as vesicular drug delivery system. J Appl Pharm Sci. 2012; 02(06):20-32.

. Diljyot K. Niosomes: A new approach to targeted drug delivery. Int J Pharm Phytopharmacol Res. 2012; 2(1):53-59.

. Kaur K, Jain S, Sapra B, Tiwary AK. Niosomal gel for site-specific delivery of anti-arthritic drug: in vitro-in vivo evaluation. Curr Drug Deliv. 2007; 4:276-282.

. Hong M, Zhu S, Jiang Y, Tang G, Pei Y. Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferring. J Control Release. 2009; 133:96-102.

. Balakrishan P, Shanmugam S, Lee WS, Lee WM, Kim JO, Oh DH, Kim DD, Kim JS, Yoo BK, Choi HG, Woo JS, Yong CS. Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery. Int J Pharm. 2009; 377:1-8.

. Bhaskaran S, Lakshmi PK. Comparative Evaluation of niosomes formulations prepared by different techniques. Acta Pharmaceutica Sciencia. 2009; 51:27-32.

. Sathali AAH, Rajalakshmi G. Evaluation of transdermal targeted niosomal drug delivery of terbinafine hydrochloride. Int J Pharm Tech Res. 2010; 2(3): 2081-2089.

. Hashim F, Ridy MEI, Nasr M, Abdallah Y. Preparation and characterization of niosomes containing ribavirin for liver targeting. J Drug Deliv. 2010; 17(5): 282-287.

. Das MK, Palei NN. Sorbitan ester niosomes for topical delivery of rofecoxib. Indian J Exp Biol. 2011; 49:438-445.

. Srinivas S, Kumar YA, Hemanth A, Anitha M. Preparation and evaluation of niosomes containing aceclofenac. Dig J nanomater biostr. 2010; 5(1):249-254.

. Attia IA, EI Gizawy Sanaa, Fouda MA, Donia AM. Influence of a niosomal formulation on the oral bioavailability of acyclovir in rabbits. AAPS Pharm Sci Tech. 2007; 8(4):E1-E7.

. Sambhakar S, Singh B, Paliwal SK, Mishra PR. Niosomes as a potential carrier for controlled release of cefuroxime axetil. Asian J Biochem Pharm Res. 2011; 1(1):126-136.

. Tamizharasi S, Dubey A, Rathi V, Rathi JC. Development and characterization of niosomal drug delivery of gliclazide. J Young Pharm. 2009; 1(3):205-209.

. Jadon PS, Gajbhiye V, Jadon RS, Gaybhiye KR, Narayanan G. Enhanced oral bioavailability of griseofulvin via niosomes. AAPS Pharm Sci Tech. 2009; 10(4):1186-1192.

. Bayindir ZS, Yuksel N. Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery. J Pharm Sci. 2010; 99(4):2049-2060.

. Palozza P, Muzzalupo R, Trombino S, Valdannini A, Picci N. Solubilization and stabilization of b-carotene in niosomes: delivery to cultured cells. Chem Phy Lipid. 2006; 139: 32-42.

. Shivanand P. Development and characterization of cefpodoxime proxetil niosomes. Int J Pharm World Res. 2010; 1(3):1-11.

. Sharma SK, Chauhan M, Pillay N, Kumar A. Span-60 niosomal oral suspension of fluconazole: formulation and in vitro evaluation. J Pharm Res Health care. 2009; 1(2):142-156.

. Kerr DJ, Rogerson A, Morrison GJ, Florence AT, Kaye SB. Antitumor activity and pharmacokinetics of niosome encapsulated adiramycin in monolayer, spheroid and xenograft. Br J Cancer. 1988; 58:432-436.

. Karki R, Mamatha GC, Subramanya G, Udupa N. Preparation, characterization and tissue disposition of niosomes containing isoniazid. Rasayan J Chem. 2008; 1(2):224-227.

. Singh G, Dwivedi H, Saraf SK, Saraf SA. Niosomal delivery of isoniazid- development and characterization. Trop J Pharm Res. 2011; 10(2):203-210.

. Ahuja N, Saini V, Bishnoi VK, Garg A, Hisoria M, Sharma J, Nepali K. Formulation and evaluation of lansoprazole niosome. Rasayan J. Chem. 2008; 1(3):561-563.

. Singh CH, Jain CP, Bairwa NK. Formulation, characterization, stability and in vitro evaluation of nimesulide niosomes. Pharmacophore. 2011; 2(3):168-185.

. Pardakhty A, Varshosaz J, Rouholamini A. In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin. Int J Pharm. 2007; 328:130-141.

. Jain CP, Vyas SP, Dixit VK. Niosomal system for delivery of rifampicin to lymphatics. Indian J Pharm Sci. 2006; 68(5):575-578.

. Guinedi AS, Mortada ND, Mansour S, Hathout RM. Preparation and evaluation of reversr-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide. Int J Pharm. 2005; 306:71-82.

. Gupta N, Shrivastava V, Saxena S, Pandey A. Formulation and evaluation of non-ionic surfactant vesicles (niosomes) for ocular delivery of ofloxacin. Int J Pharm life Sci. 2010; 1(7): 413-418.

. Modi KA, Shelat PK. Formulation and development of topical niosomal gel of BCS class-3 anti-viral drug for better efficacy as herpes treatment. Int Res J Pharm. 2012; 3(3):271-276.

. Sathyavathi V, Hasansathali AA, Ilavarasan R, Sangeetha T. Formulation and evaluation of niosomal in situ gel ocular delivery system of brimonidine tartarate. Int J Life Sci Pharm Res. 2012; 2(1):L-82- L-95.

. Tavano L, Alfano P, Muzzalupo R, Cindio BD. Niosomes vs microemulsions: new carriers for topical delivery of capsaicin. Colloid Surf B: Biointerface. 2011:1-7.

. Agarwal R, Katare OP, Vyas SP. Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol. Int J Pharm.2001; 228:43-52.

. Paolino D, Cosco D, Muzzalupo R, Trapasso E , Picci N, Fresta M. Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer. Int J Pharm. 2008; 353:233-242.

. Manosroi A, Khanrin P, Lohcharoenkal W, Werner RG, Götz F, Manosroi W, Manosroi J. Transdermal absorption enhancement through rat skin of gallidermin loaded in niosomes. Int J Pharm. 2010; 392:304-310.

. Gupta KS, Nappinnai M, Gupta VRM. Formulation and evaluation of topical meloxicam niosomal gel. Int J Biopharm. 1; 2010:7-13.

. Arora D, Khurana B, Kumar MS, Vyas SP. Oral immunization against hepatitis B virus using mannosylated bilosomes. Int J Recent Adv Pharm Res. 2011; 1:45-51.

. Schiff ER, Dietschy JM. Current concepts of bile acid absorption. Am J Clin Nutr. 1969; 22(3):273-278.

. Shukla A, Khatri K, Gupta PN, Goyal AK, Mehta A and Vyas SP. Oral immunization against hepatitis B using bile salt stabilized vesicles (bilosomes). J Pharm Pharm Sci. 2008; 11(1):59-66.

. Chaudhari MJ, Pandya DP, Thakkar PP, Soni AM, Modi DA. Aquasomes: a novel drug delivery system. Int J Pharm Res Scholar. 2012; 1(2):485-489.

. Umashankar MS, Sachdeva RK, Gulati M. Aquasomes: a promising carrier for peptides and protein delivery. Nanomed Nanotechnol Biol Med. 2010; 6:419-426.

. Sutariya V, Patel P. Aquasomes: a novel carrier for drug delivery. Int J Pharm Sci Res. 2012; 3(3):688-694.

. Vengala P, Dintakurthi S, Aslam S, Gollagudem R, Kumaraswamy P. Aquasomes: a novel drug carrier system. Int Res J Pharm. 2012; 3(4):123-127.

. Sethi P, Sharma A, Patel SN, Singhai AK. Aquasome-a novel carrier system. Int J Pharm Life Sci. 2010; 1(4):222-225.


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