Targeted Drug Delivery System using Photovoltaic Devices



Advances in surgical techniques and scientific research, including the development of new cytotoxic drugs and hormonal therapies, have resulted in better treatment options for cancer patients. Despite such encouraging progress, systemic oral or intravenous administration can cause severe cytoxicity, which limits the therapeutic potential of anticancer drugs. Recent discovery using solar cells for targeted drug delivery will pave the way for the development and introduction of innovative targeted therapies with improved efficacy. A photovoltaic cell holds opposite charges on its surfaces, serve as a new drug delivery system to carry cancer chemotherapeutic drugs or substances and release them when the charge intensity or polarity changes upon external photo stimulation or laser source. In this new strategy using photovoltaic device, a hypothesis is proposed to serve as a new drug delivery method. Positively charged Poly-L-Lysine and negatively charged Bovine Serum Albumin are attached the negative side and positive side of a solar cell respectively. Experimental data reveals that the PV cells significantly can release the charged molecules upon external photo stimulation, which suggests the PV has potential to be used as a new drug delivery system to carry cancer chemotherapeutic drugs.


Cancer, Cytotoxicity, Antitumor Activity, Oral, Intravenous Administration

Full Text:



Yiyao Liu, Hirokazu Miyoshi,Michi hiru Nakmura, Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticle, Article first published online: 27 MAR 2007 DOI :10: 1002/ijc.22709

J. Jhang et al. Design of Nanoparticles as Drug Carriers for Cancer Therapy, cancer genomics & proteomics 3: 147-158 (2006),

Ashutos Chikoti, Mathew R Dreher, Dan E. Meysr and Drazen Raucher. Targeted drug delivery by thermally responsive polymers. Advance drug delivery, 10/2002; 54(5): 613-30

Califano, F.P., Current Utilization of Photovoltaic Effect. Chimica & L Industria, 1975.57(4): p. 293- 293.

Chen, L.J., et al., Photovoltaic effect in a periodically poled lithium niobate Solc-typewavelength filter. Applied Physics Letters, 2006. 88(12)

Ning-Ping Huang, R.M., Janos Voros, Marcus Textor, Rolf Hofer, Antonella Rossi, Donald L. Elbert,Jeffrey A. Hubbell, and Nicholas D. Spence, Poly(l-lysine)-g-poly(ethylene glycol) Layers on Meta Oxide Surfaces: Surface-Analytical Characterization and Resistance to Serum and Fibrinogen Adsorption. American Chemical Society, 2001.

Alfred V. Elgersma, R.L.J.Z., Willem Nordea and Johannes Lyklema, The adsorption of bovine serum albumin on positively and negatively charged polystyrene latices, Elsevier,2004.

Langer R. Drug delivery: drugs on target. Science 2001; 293: 58–9.

Alexiou C, Schmid RJ, Jurgons R, Kremer M, Wanner M, Bergemann C, Huenges E, Nawroth ,T, Arnold W, Parak FG. Targeting cancer cells: magnetic nanoparticles as drug carriers. Eur Biophys J 2006; 35: 446–50.

Daniel Cole, Surface chemistry and Adhesive properties of oxidized Si-Surfaces, November,2007, PhD dissertation, Quens’ College, Universitu of Cambridge, UK

Nobs L, Buchegger F, Curny R, Allemann E. Current methods for attaching targeting ligandsto liposomes and nanoparticles. J Pharm Sci 2004; 93: 1980–92.

Allen TM. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002; 2: 750–63.

Ding BS, Dziubla T, Shuvaev VV, Muro S, Muzykantov VR. Advanced drug delivery systemsthat target the vascular endothelium. Mol Interv 2006; 6: 98–112.

Ehrhardt C, Kneuer C, Bakowsky U. Selectin an emerging targeting for drug delivery. Adv Drug Deliv Rev 2004; 56: 527–49.

Eliceiri BP, Cheresh DA. Adhesion events in angiogenesis. Curr Opin Cell Biol 2001; 13: 563–88.

Dagar S, Sekosan M, Lee BS, Rubinstein I, Onyuksel H. VIP receptors as molecular targets of breast cancer: implications for targeted imaging and drug delivery. J Controlled Release 2001; 74: 129–34.

Arap W, Pasqualini R, Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 1998; 279: 377–380.

Sahoo SK, Labhasetwar V. Nanotech approaches to drug delivery and imaging. Drug Discov Today 2003; 8: 1112–20

Fahmy TM, Fong PM, Goyal A, Saltzman WM. Targeted for drug delivery. Nanotoday 2005:18-20

Fahmy TM, Samstein RM,Harness CC, Saltzman WM. Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting. Biomaterials, 2005; 26:5727–36

Couvreur P, Barratt G, Fattal E, Legrand P,Vauthier C. Nanocapsule technology: a review. Crit Rev The Drug Carrier Syst 2002; 19: 99–134.

Cegnar M, Premzl A, Zavasnik-Bergant V. Kristl J. Kos J. Poly (lactide-co-glycolide) as a carrier system for delivering cysteine protease inhibitor cystatin into tumor cells. Exp Cell Res 2004; 301: 223–31

Farokhzad OC, Jon S, Khademhosseini A,Tran TN,Lavan DA, Langer R. Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res,2004; 64: 7668–72.

Fonseca MJ, Jagtenberg JC, Haisma HJ, Storm G. Liposome-mediated targeting of enzymesto cancer cells for site-specific activation of prodrugs: comparison with the corresponding antibody-enzyme conjugate. Pharm Res 2003; 20: 423–8.

McCarthy JR, Perez JM, Bruckner C, Weissleder R. Polymeric nanoparticle preparation that eradicates tumors. Nano Lett 2005; 5: 2552–6.

Farokhzad OC, Cheng J, Teply BA, Sherifi I, Jon S, Kantoff PW, Richie JP, Langer R. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci,USA 2006; 103: 6315–20.

Cheng J, Teply BA, Sherifi I, Sung J, Luther G, Gu FX, Levy-Nissenbaum E, Radovic-Moreno AF, Langer R, Farokhzad OC. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 2007; 28: 869–76.

Kukowska-Latallo JF,Baker JRJr. Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex. Adv Drug Deliv Rev 2005; 57: 2203–14.Kukowska-Latallo

JF, Candido KA, Cao Z, Nigavekar SS, Majoros IJ, Thomas TP, Balogh LP, Khan MK, Baker JRJr. Nanoparticle targeting of anticancer drug improves therapeutic Response in animal model of human epithelial cancer. Cancer Res 2005; 65: 5317–24.

Moan J, Berg K (1991) The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochem Photobiol 53:549–553

R. Weissleder, A clean vision for in vivo imaging, Nat. Biotechnol. 2001 , 19 , 316 .

C. R. Simpson, M. Kohl, M. Essenpreis, M. Cope, Phys. Med. Biol. 1998 , 43 , 2465 .

V. Ntziachristos, J. Ripol, L. H. V.Wang, R.Weissleder, Nat.Biotechnol. 2005 , 23, 313

Dickerson EB, P.S., Gold nano rod assisted near-infrared. nature 2008

Gregory N. Nielson, M.O., Paul Resnick, Jose L. Cruz-Campa, Tammy Pluym, Peggy J. Clews, Elizabeth Steenbergen, Vipin P. Gupta, MICROSCALE C-SI (C)PV CELLS FOR LOW-COST POWER. IEEE, 2009, (Sandia National Laboratories).


  • There are currently no refbacks.

Copyright (c)

               AR Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India (Design) 2009-2021


Follow @arjournals on Twitter