Development and In Vitro Evaluation of Matrix Type Transdermal Delivery of Ondansetron Hydrochloride

Rajan Rajabalaya, Choo Hwai Qin, Sheba Rani Nakka David

Abstract


Release and permeation studies were carried out with the objective of developing transdermal therapeutic systems with Ondansetron Hydrochloride (OS). The patches were prepared with Eudragit RSPO/RLPO as polymer and dibutyl sebacate (DBS) and triethyl citrate (TEC) as the plasticizer in different compositions. Thickness, tensile strength, drug content, moisture content and water absorption studies of the patches were measured. In vitro release/permeation of OS was studied by using a Franz diffusion cell. Chemical enhancers like eugenol and Virgin linseed oil were added to compare the release pattern of the drug. All the formulations are developed and passed the mechanical as well as physiochemical properties, while in the case of release profile, the patch containing DBS had better percentage cumulative release compared to those with TEC containing patches. Eugenol acted as a good chemical enhancer as it increased percentage of permeation compared to linseed oil significantly. The ratio of Eudragit RSPO/RLPO (1:1) with combination of using 25% DBS as plasticizer and 3% eugenol as chemical enhancer favourable release profile.  The selected formulations may be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.


Keywords


Ondansetron Hydrochloride; dibutyl sebacate; triethyl citrate; eugenol; linseed oil

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