Self-nanoemulsifying Drug Delivery Systems of Valsartan: Preparation and In-Vitro Characterization

Rajinikanth PS, Neo Woei Keat, Sanjay Garg


The main objective this study is to prepare and evaluate the selfnanoemulsifying drug delivery (SNEDDS) system in order to achieve a better dissolution rate of a poorly water soluble drug valsartan.  The present research work describes a SNEDDS of valsartan using labrasol, Tween 20 and Polyethylene glycol (PEG) 400. The pseudo-ternary phase diagrams with presence and absence of drug were plotted to check for the emulsification range and also to evaluate the effect of valsartan on the emulsification behavior of the phases. The mixtures consisting of oil (labrasol ) with surfactant (tween20), co-surfactant (PEG 400) were found to be optimum formulations. Prepared formulations were evaluated for its particle size distribution, nanoemulsifying properties, robustness to dilution, self emulsication time, turbidity measurement, drug content and in-vitro dissolution. The optimized formulations  are further evaluated for heating cooling cycle, centrifugation studies, freeze thaw cycling, particle size distribution and zeta potential were carried out to confirm the stability of the formed SNEDDS formulations. The prepared formulation has a significant improvement in terms of the drug solubility as compared with marketed tablet and pure drug, thus, this greater dissolution of valsartan from formulations could lead to higher absorption and higher oral bioavailability.


Self Emulsifying Drug Delivery System, Nanoemulsion, Valsartan, Enhancement of dissolution, poorly soluble drug,

Full Text:



Zaid AN et al. Formulation and bioequivalence of two Valsartan tablets after a single dose administration. Scientia Pharmaceutica 2011; 79: 123 – 135.

Novitch M. The United States Pharmacopoeia: The National Formulary Asian Edition. Tata Press Limited. USA: 1994.

Siddiqui N et al. Pharmacacological and pharmaceutical profile of Valsartan: A Review. Journal of Appl Pharmal Sci. 2011; 01 (04): 12 – 19.

Saydam M, Takka S. Bioavailability file: Valsartan. FABAD J Pharm Sci 2007; 32: 185 – 196.

DrugBank: Open Data Drug & Drug Target. 2007. Available from:

Patel SN et al. Self-emulsifying drug delivery system. J Global Tech 2010; 2(2): 29 – 37.

Tang J, Sun J, He ZG. Self-Emulsifying Drug Delivery Systems: Strategy for improving oral delivery of poorly soluble drugs. Current Drug Therapy 2007; 2: 85 – 93.

Date AA, Desai N, Dixit R & Nagarsenker M. Self-nanoemulsifying Drug Delivery Systems: Formulation insights, applications and advances. Nanomedicine 2010; 5(10).

Nielsen FS, Petersen KB & Müllertz A. Bioavailability of Probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur J Pharm Biopharm 2008; 69: 553-62.

Kumar GP, Rambhau D, Aapte SS. Oral bioavailability enhancement of Carbamazepine in healthy human volunteers. J Pharm Research 2011 Jan 13rd; 4(2): 361-5.

Taha EI, Al-Saidan S, Samy AM, Khan MA. Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Intr J Pharm 2004; 11( 285)109-19.

Mahmood EA, Bendas ER, Mohamed MI. Preparation and evaluation of self-nanoemulsifying tablets of Carvedilol. AAPS 2009 Feb 24; 10(1):9192-7.

Jeevana JB & Sreelakshmi K. Design and evaluation of self-nanoemulsifying drug delivery system of Flutamide. J Young Pharm 2011; 3(1): 4-8.

Dixit AR, Rajput SJ & Patel SG. Preparation and bioavailability assessment of SMEDDS containing Valsartan. AAPS 2010 Feb; 11(1):314-21

Patel AR, Vavia PR. Preparation and in vivo evaluation of SMEDDS (Self-Microemulsifying Drug Delivery System) containing Fenofibrate. AAPS Journal 2007; 9(3): 344 – 352.

Gupta AK et al. Preparation and in-vitro evaluation of self-emulsifying drug delivery system of antihypertensive drug Valsartan. Intr J Pharma and Life Sciences March 2011; 2(3): 633 – 639.

Parambi DGT, Mathew M, Ganesan V. A validated stability indicating HPLC method for the determination of Valsartan in tablet dosage forms. Journal of Applied Pharmaceutical Science. June 2011; 01(04): 97 – 99.

Dey S et al. Development and validation of a UV-Vis Spectrophotometric method for the estimation and degradation monitoring of Cefradroxil in bulk and pharmaceutical dosage forms. International Journal of Chemistry Research. May 2010; 1(1): 29 – 35.

Shafiq-un-Nabi S et al. Formulation development and optimization using nanoemulsion technique: A technical note. AAPS PharmSciTech 2007; 8(2): Article 28.

Griffin WC. Calculation of HLB values of non-ionic surfactants. J. Soc. Cosmet. Chem. (1954): 259.

Pasquali RC, Taurozzi MP & Bregni C. Some considerations about the hydrophilic-lipophilic balance system. Int. J. Pharm 2008 May 22; 356(1 – 2): 44 – 51.

Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev 1997; 25: 47 – 58.

Particle Sciences Drug Development Services. Emulsion stability and testing. Tehnical Brief 2011 Volume 2. [cited 2011 July 30]. Available from:

Colloidal Dynamics. The zeta potential. [cited 2011 July 27]. Available from:

Mason TG, Wilking JN, Meleson K, Chang CB & Graves SM. Nanoemulsions: Formation, structure and physical properties. J. Phys: Condens. Matter 18 (2006) R635–R666.


  • There are currently no refbacks.

Copyright (c)

               AR Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India (Design) 2009-2021


Follow @arjournals on Twitter