Photoprotective herbal extract loaded nanovesicular creams inhibiting ultraviolet radiations induced photoaging

Chanchal Deep Kaur, Swarnlata . Saraf


Botanical photochemopreventives are used to fight against the adverse effects of ultra violet rays on skin which leads to photoaging.  Phytoconstituents present in Punica granatum extract have antioxidant, anti-carcinogenic and photoprotective properties which was proved by estimation of phenolic content, sun protection factor and antioxidant effect determination of the alcoholic extract. Extract loaded nanotransfersomes were prepared, evaluated for size, entrapment efficiency and incorporated into the cream. The presence of vesicles in the cream was confirmed by the transmission electron microscopy and the efficacy of the formulated creams by the physicochemical parameters. The nanotransfersomal and conventional cream formulations were in vivo tested for change in skin hydration (Corneometer), viscoelasticity (Cutometer) and sebum content (Sebumeter) . The photoprotective effect of formulations was further confirmed by biochemical studies. Improved skin properties (viscoelasticity, skin hydration, sebum content) and biochemical parameters (superoxide dismutase, catalase, total protein and ascorbic acid level) with decreased malondialdehyde level was observed with nanotransfersomal cream formulations as compared to conventional creams. The efficacy was in the order nanotransfersomal creams > Conventional creams> Empty nanotransfersomal cream > Base cream.


Herbal nanovesicles; ellagic acid; photo protective creams; photoaging; nanotransfersomes

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