Buccal Mucosa A Gifted Choice For Systemic Drug Delivery

G. Parthasarathy, K. Bhaskar, K. N Jayaveera, Prasanth V. V


The main aim of pharmaceutical research is steadily shifted from the development of new chemical entities to the development of novel drug delivery system of existing drug molecule to maximize their effectiveness in terms of therapeutic action, patent protection, patient compliance and reduced adverse effects. In the recent years the interest is growing to develop a drug   delivery system with the use of a mucoadhesive polymer that will attach to related tissue or to the surface coating of the   tissue for targeting various absorptive mucosa such as ocular, nasal, pulmonary, buccal, vaginal, etc. This system of drug delivery is called mucoadhesive drug delivery system. The buccal region of oral cavity is an attractive target for administration of drug of choice. Buccal drug delivery involves the administration of desired drug through the buccal mucosal lining of the oral cavity. Other than the common advantages of novel drug delivery systems, buccal mucosa has several specific advantages like, faster and richer blood flow, lesser thickness of the buccal mucosa and increased permeability, low enzymatic activity in the buccal mucosa and versatility in designing unidirectional release systems to overcome the first-pass metabolism and subsequent low bioavailability of the drug.

Key words: Buccal mucosa, mucoadhesion, permeation enhancers, novel drug delivery, buccal adhesive polymers


Buccal mucosa, mucoadhesion, permeation enhancers, novel drug delivery, buccal adhesive polymers

Full Text:



Ding X, Alani AWG, Robinson JR. Extended release and Targeted Drug Delivery System. In: Troy DB, Remington: The Science and Practice of Pharmacy, 21st ed. Lipincott Williams and Wilkins. Philadelphia 2006;939-940.

Shojaei AH, Chang RK, Guo X, Burnside BA, Couch RA. Systemic drug delivery via the buccal mucosal route. Pharm Tech 2001; 70-81.

Shojaei AH. Buccal mucosa as a route for systemic drug delivery: A Review. J Pharm Pharmaceut Sci 1998; 1: 15-30.

Rathbone MJ, Drummond BR, Tucker IG. The oral cavity as a site for systemic drug delivery. Adv Drug Delivery Rev 1994; 13: 1-22.

Hoogstraate Janet AJ, Wertz PW. Drug delivery via the buccal mucosa. Pharmaceutical Science & Tech Today 1998; 1: 309-316.

Smart JD. Drug delivery using buccal adhesive systems. Adv Drug Delivery Rev 1993; 11: 253-270.

Senel S, Hincal AA. Drug permeation enhancement via buccal route: possibilities and limitations. J Control Rel. 2001; 72: 133-144.

Carvalho F C, Bruschi M L, Evangelista R C, Gremiao MPD , Mucoadhesive drug delivery systems. Braz. J. Pharm. Sci.2010;46.

Khanna R, Agarwal SP, Ahuja Alka. Mucoadhesive buccal drug delivery: A potential alternative to conventional therapy. Ind J Pharm Sci 1998; 60: 1-11.

Harris D, Robinson JR. Drug delivery via the mucus membranes of the oral cavity. J Pharm Sci. 1992; 81: 1-10.

Nagai T, Konishi R. Buccal/gingival drug delivery systems. J Control Rel. 1987; 6: 353- 360.

Mc Elnay CJ, Buccal Absorption of Drugs. In: Swarbrick J, Boylan JC editors. Enclyclopedia of Pharmaceut Tech. New York: Marcel Dekker 2002; 2: 189-211.

Webber W. Mucosal Drug Delivery, Buccal. In: Edith Mathiowitz, editor. Encyclopedia of Controlled Drug Delivery. New York: John Wiley and Sons. Inc., 1999; 2:553- 563.

Gupta A, Garg S, Khar RK. Mucoadhesive drug delivery systems: A Review. Ind Drugs 1992; 29(13): 586-593.

Goswami SK. Bioadhesive dosage forms: An overview. The Eastern Pharmacist. 1994; 85-87.

Chowdary KPR, Srinivas L. Mucoadhesive drug delivery systems: A review of current Status. Ind Drugs 2000; 37: 400-406.

Weatherell JA, Colin R, Rathbone MJ. Site specific differences in the salivary concentrations of substances in the oral cavity- Implications for the aetiology of oral disease and local drug delivery. Adv Drug Delivery Rev. 1994; 13: 23-42.

Shojaei Amir H, Buccal Mucosa As A Route For Systemic Drug Delivery: A Review. J Pharm Pharmaceut Sci. 1998;1:15-30.

Salamat Miller N, Chittchang M, and Johnston T.P, The use of mucoadhesive polymers in buccal drug delivery, Adv. Drug. Deliv. Rev. 2005;57: 1666–1691.

Gandhi R.B, and Robinson J.R, Bioadhesion in drug delivery Indian J.Pharm sci.1988;50: 145-152.

Sudhakar Y, Kuotsu K and Bandyopadhyay A.K, Buccal bioadhesive drug delivery - a promising option for orally less efficient drugs, J. Control. Rel. 2006;114:15-40.

Rathbone MJ, Tucker IG. Mechanisms, barriers and pathways of oral mucosal drug permeation. Adv Drug Delivery Rev. 1993; 12: 41-60.

Chidambaram N, Srivastava AK. Buccal drug delivery systems. Drug Dev Ind Pharm. 1995; 21: 1009-1036.

Pramod Kumar TM, Desai KG, Shivakumar HG. Mechanism of buccal permeation enhancers. Ind J Pharm Edu. 2002; 36: 147-151.

Ganem-Quintanar A, Falson-Reig F, Buri P. Contribution of lipid components to the permeability barrier of oral mucosa. Eur J Pharm and Biopharm. 1997; 44: 107-120.

Dominique Duenene, Gilles Ponchel. Bioadhesion of solid oral dosage forms, Why and How. European Journal of Pharmaceutics & Biopharmaceutics. 1997; 44: 15-8.

Globodanka Tamburic, Duncan QM Craig. A comparison of different in vitro methods for measuring mucoadhesive performance. European Journal of Pharmaceutics & biopharmaceutics. 1997; 44: 159-8.

Jin Whan Lee, Jae Han Park, Joseph Robinson R. Bioadhesive-based dosage forms. The Next Generation Journal of Pharmaceutical Science. 2000 ; 85: 850-17.

James Swarbrick, Bioadhesive Drug Delivery Systems. 1st Ed. Marcel Dekker Inc., New York: 1999;541- 562.

Miller NS, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005; 57: 1666-91.

John DS. The basic and underlying mechanism of mucoadhesion. Advanced drug delivery reviews. 2005; 57: 1556-1568.

Devarajan PV, Gandhi AS. In: Advances in controlled and Novel Drug Delivery. 1st ed. Jain NK, New Delhi: CBS publishers and Distributers 2001;72-82.

John DS. The basic and underlying mechanism of mucoadhesion. Advanced drug delivery reviews. 2005; 57: 1556-1568.

Mishra PR, Namdeo A, Jain S, Jain NK. Hydrogels as drug delivery system. Indian Drugs. 1996; 33: 181–186.

Jimenez-Castellanos MR, Zia H, Rhodes CT. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm. 1993; 19: 143-194.

Puratchikody A, Prasanth VV, Sam T. Mathew, Ashok Kumar B. International Journal of Drug Delivery, 2011;3:171-184.


  • There are currently no refbacks.

Copyright (c)

               AR Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India

Copyright@arjournals.org (Design) 2009-2021


Follow @arjournals on Twitter