Preparation and Evaluation of Diclofenac Potassium loaded Agarose Beads.

Anindya Kishore Maiti, Bhaskar Mazumdar, Amal Kumar Dhara, Arunabha Nanda


Controlled release technology has emerged to be an important area of research in the field of novel drug delivery system. Being a member of controlled release system, microspheres are very useful for achieving therapeutic response for improving patient compliance. Microspheres of diclofenac potassium were prepared by using cold gelation technique with the help of a biodegradable polymer-agarose. Beads were prepared by dropping a hot aqueous agar solution in to a beaker containing a mixture of chilled light liquid paraffin and water. pH of water was adjusted 1.60 by adding concentrated hydrochloric acid to reduce the prior diffusion of diclofenac potassium. Drug release profile (in-vitro release), swelling index, particle size analysis, entrapment of drug into beads were investigated. Scanning electron microscopy (SEM) was carried out for characterisation of beads.


Microsphere; Diclofenac potassium; Agarose; SEM

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George, M., Grass, I.V. and Robinson, J.R. Sustained and controlled release drug delivery systems.; 1989; Modern Pharmaceutics (Banker GS, Rhodes CT Eds). 2, 575-609 .

Tilak, R., Bhardwaj, Meenakshi, K., Roshan, L. and Anubha, G., Natural Gums and Modified Natural Gums as Sustained-Release Carriers.; 2000; Drug Development and Industrial Pharmacy. 26: 1025-1038.

Halder, A.;Maiti,S.; Sa,B. Entrapment efficiency and release characteristics of polyethyleneimine-treated or untreated calcium alginate beads loaded with propranolol-resign complex.; 2005; Int. J. Pharm., v.302, p.84-94.

Waki S, Harvey JD, Bellarmy AR. Study of agarose gels by electron microscopy of freeze fractured surfaces.; 1982; Biopolymers. 21:1909-1926.

Kay AE, Alldred A. Rheumatoid Arthritis and Osteoarthritis, In Walker R., Edwards C.,(ed.); 2003; Clinical Pharmacy and Therapeutics. 3rd ed, pp. 791- 807 Churchill Livingstone,London.

Poli A, Moreno RA, Ribeiro W, Dias HB, Moreno HJ, Muscara MN, De Nucci G. Influence of gastricacid secretion blockade and food intake on the bioavailability of a potassium diclofenac suspension in healthy male volunteers. Influence of gastric acid secretion blockade and food intake on the bioavailability of a potassium diclofenac suspension in healthy male volunteers.; 1996; Int J Clin Pharmacol Ther 34:76–79.

Fini A, Garuti M, Fazio G, Alvarez-Fuentes J, Holgado MA. Diclofenac salts. I. Fractal and thermal analysis of sodium and potassium diclofenac salts.; 2001; J Pharm Sci 90:2049–2057.

Tripathi KD. Essential of medical pharmacology. 1998; 4th Edition. Delhi: Jaypee Brothers medical Publishers (P) Ltd.

Moore N. Diclofenac potassium 12.5 mg tablets for mild to moderate pain and fever: A review of its pharmacology, clinical efficacy and safety.; 2005; Clin Drug Invest 27:163–195.

Riess W, Stierlin H, Degen P, Faigle JW, Gerardin A, Moppert J, Sallmann A, Schmid K, Schweizer A, Sulc M, Theobald W, Wagner J. Pharmacokinetics and metabolism of the anti-inflammatory agent Voltaren.; 1978; Scand J Rheumato Suppl 22:17–29.

Fattah, D.J.W., Grant, K.E., Gaber and Meshali, M.M. Physical characteristics and Release behavior of salbutamol sulfate Beads prepared with different Ionic polysaccharides.; 1998; Drug development and Industrial Pharmacy. 24, 541-547.


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