Acute effect of gibberellic acid on serum enzymes and blood markers in male albino rats

S. Muthu, P. Muthuraman, V. Muthuviveganandavel, K. Srikumar


This study was designed to evaluate the influence of a phytohormone, gibberellic acid (GA3) on marker enzymes and biomarkers of serum, and blood hemoglobin and its blood cells counts of rat. In order to evaluate the positive/negative effects, the rats were administered 75μg, 150μg and 300μg of GA3/kg body weight as a single dose. GA3 treatments produced differential effects on the different parameters at dose dependent manner after 4 hours.The down regulation in specific activities of ALT, ALP, GGT and amylase were noted against the control with significant up regulation of AST activity. GA3 also produced dose dependent effect on biomarkers. There is a substantial reduction in the quantity of glucose, urea, creatinine, calcium, phosphorus, sodium and potassium was recorded against the control. On the other hand, the insignificant increase in content of total protein, albumin and uric acid was observed at all dose of GA3 treatment against the control. GA3 increased the RBC, WBC and neutrophil by decreasing the lymphocyte total numbers. Platelets, monocytes and oesinophils count were not altered by any dose of GA3.In conclusion, GA3 produced dose dependent effect on different parameters of rat blood serum.

Keywords: phytohormone; gibberellic acid; creatinine; neutrophil


phytohormone; gibberellic acid; creatinine; neutrophil

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