A review on factors affecting the design of nasal drug delivery system

Ram Chand Dhakar, Sheo Datta Maurya, Vijay K Tilak, Anish K Gupta

Abstract


Transmucosal nasal delivery is a promising drug delivery option where common drug administrations (e.g., intravenous, intramuscular, or oral) are inapplicable. Recently, it has been shown that many drugs have better bioavailability by nasal route than by oral route. This has been attributed to rich vasculature and a highly permeable structure of the nasal mucosa coupled with avoidance of hepatic first-pass elimination, gut wall metabolism and/or destruction in the gastrointestinal tract. The physiology of the nose presents obstacles, but offers a promising route for non-invasive systemic delivery of numerous therapies and debatably drug delivery route to the brain. To overcoming problems in nasal drug delivery requires deep understanding of the various factors affecting nasal delivery. Thus present review focuses on various aspects of nasal drug delivery with special emphasis to factors affecting nasal drug administration.

Keywords: Transmucosal nasal delivery, hepatic first-pass metabolism, non-invasive, microemulsions, microspheres.


Keywords


Transmucosal nasal delivery, hepatic first-pass metabolism, non-invasive, microemulsions, microspheres.

Full Text:

PDF

Refbacks

  • There are currently no refbacks.




Copyright (c)

               AR Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India

Copyright@arjournals.org (Design) 2009-2021

 

Follow @arjournals on Twitter