Development and in vivo evaluation of mucoadhesive tablets of Lafutidine

Ganesh Kumar Gudas, A Jaswanth, DVRN Bhikshapathi


The aim of the present work was in vitro and in vivo evaluation of mucoadhesive tablets of lafutidine to prolong the gastric residence time after oral administration. Formulations were prepared using 33 full factorial designs to explore the effects of Gum Kondagogu, Gum Olibanum and Guar Gum (as independent variables) on mucoadhesive strength, drug release and Ex vivo residence time (as dependent variables) was studied and published in the earlier research paper.

In this investigation the formulated mucoadhesive tablets which was optimized through in vitro studies is selected and performed the in vivo studies on Human volunteers. The drug-polymer interaction was also studied by conducting FTIR and DSC tests. The in vitro release kinetics studies reveal that all formulations fits well with Zero order, followed by Korsmeyer-Peppas, Higuchi and the mechanism of drug release is erosion. After analysis of different evaluation parameters and drug release kinetics, formulation code F22 was selected as a promising formulation for delivery of lafutidine as a mucoadhesive Gastroretentive tablet with best mucoadhesive strength and 99.54% drug release at 12th hour. Radiological evidences suggest that, a formulated tablet was well adhered for >10 h in human stomach. The bioavailability studies of F22 containing lafutidine was carried out which exhibited increased pharmacokinetic parameters of Cmax (268±1.26), Tmax (1.30±1.23 h) and AUC0-t (1048±16.42) as compared to marketed formulations which indicates improved bioavailability of formulations. 


Lafutidine, Mucoadhesive, Radiographic studies, In vivo bioavailability studies.

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Deshpande AA, Rhodes CT, Shah NH, Malick AW. Controlled release drug delivery systems for prolonged gastric residence: an overview. Drug Dev Ind Pharm. 1996; 22 (6): 531-539.

Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Rel. 2000; 63(3): 235–259.

Chavanpatil MD, Jain P, Chaudhari S, Shear R, Vavi PR. Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. Int J Pharm. 2006; 316(1): 86–92.

Park, K. Robinson, J.R. Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion. Int J Pharm. 1984; 19(2): 107–127.

Shinde A J. Gastro retentive Drug Delivery System: An

Hwang S J. Park H. and Park K..Gastric Retentive Drug-Delivery Systems Critical Reviews in Therapeutic Drug Carrier Systems.1998:15(3):243–284.

Whitehead L. Fell J T and Collett J H. Development of a Gastroretentive Dosage Form. Eur. J. Pharm .Sci.1996:4 (1):182.

Xiaoling L. and Bhaskara R J. Design of controlled release drug delivery systems. Mc Graw Hill,New York. 2006: 173-176.

Deshpande A. A.Rhodes C T. Shah N H and Malick A W. Controlled-release drug delivery systems for prolonged gastric residence: An overview. Drug Dev Ind. Pharm.1996:22 (6):531-539.

Bardonnet P L. Faivre V. Punj W J. Piffaretti J C.and Falson F.Gastroretentive dosage forms: overview and special case of Helicobact pylori. Journal Control Release. 2006:111,1-18.

Bernkop A. Mucoadhesive polymers strategies, achievements and future challenges. Adv Drug Deliv Rev.2005: 57, 1553– 1555.

Thripathi KD, Essentials of medical pharmacology, 6th edition: 489- 90.

National Library of Medicine: Drug Information Portal.

Sweetman SC. Ed Martindale: The complete drug reference. 35th Edition Pharmaceutical Press: London 2007; 1250-1253.

Raymond J, Rowe C, Paul J Sheskey, sian c owen, editors. Handbook of pharmaceutical

excipients 5th ed. London: Pharmaceutical Press; 2009: 118-121, 110-114, 185-188, 94-98.

Prasanna Kumari et al., Design and In vivo evaluation of Metoprolol Tartrate bilayer floating tablets in healthy human volunteers. International Journal of Drug Delivery 6 (1) 14-23 2014

Bhupesh Dewan, Raghuram ChimataAn open-label, randomized, cross-over bioequivalence study of lafutidine 10 mg under fasting condition, World J Gastrointest Pharmacol Ther 2010; 1(5): 112-118

C.V.S Subrahmanyam. Textbook of Physical Pharmaceutics. N.K. Jain Publisher for Vallabh Prakashan, 11th edition, 215-224.


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