Targeting effect of folate on cancer cell through curcumin carrier nano-system

Ha Phuong Thu, Nguyen Hoai Nam, Le Quang Duong, Nguyen Thi Tham, Bui Thuc Quang, Ha Thi Minh Thi, Do Hai Doan, Hoang Thi My Nhung

Abstract


Folate receptor (FR) is well known for its overexpression on surface of various cancer cell lines, which is identical to normal tissue. Folic-based targeting drug delivery systems, therefore, are one of the most effective targeting carriers that effectively bind to FR up-regulated cancer cells. Curcumin was used both for labeling and chemotherapy. The materials were characterized and structurally confirmed by FT-IR spectra, fluorescent images and FE-SEM images. Bioassays were conducted on HeLa and HT29 cancer cell lines after 4 and 12 hours. Results show that folic acid significantly enhanced both targeting efficiency and internalization of curcumin to FR-expressing cancer cells.


Keywords


Drug delivery systems, Nanoparticle, Targeting effect, Curcumin, OCMCs, Folic acid.

Full Text:

PDF

References


. Iwamoto T. Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs. Biological and Pharmaceutical Bulletin. 2013; 36(5): 715-718.

. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003; 23(1A): 363–398.

. Wilken R, Veena MS, Wang MB and Srivatsan ES. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 2011; 10(12): 1-19.

. Darvesh AS, Aggarwal BB and Bishayee A. Curcumin and liver cancer: a review. Current pharmaceutical biotechnology. 2012; 13(1): 218-228.

. Ha PT, Tran TMN, Pham HD, Nguyen QH and Nguyen XP. The synthesis of poly (lactide)-vitamin E TPGS (PLA-TPGS) copolymer and its utilization to formulate a curcumin nanocarrier. Advances in Natural Sciences: Nanoscience and Nanotechnology. 2010; 1(1): 015012.

. Le MH, Ha PT, Nguyen TBT, Tran THH, Ha TMT, Mai TTT, Tran TNH, Do HN, Nguyen XP and Duong TQ. Preparation and Antitumor-promoting Activity of Curcumin Encapsulated by 1,3- β-Glucan Isolated from Vietnam Medicinal Mushroom Hericium erinaceum. Chemistry Letters. 2011; 40(8): 846-848.

. Ha PT, Duong TQ, Mai TTT, Tran THH, Nguyen HN, Nguyen XP, Tran TMN, Phan QT, Phan THT, Vuong TKO and Le MH. In Vitro Apoptosis Enhancement of Hep-G2 Cells by PLA–TPGS and PLA–PEG Block Copolymer Encapsulated Curcumin Nanoparticles. Chemistry Letters. 2013; 42(3): 255-257.

. Sahu SK, Mallick SK, Santra S, Maiti TK, Ghosh SK and Pramanik P. In vitro evaluation of folic acid modified carboxymethyl chitosan nanoparticles loaded with doxorubicin for targeted delivery. Journal of Materials Science: Materials in Medicine. 2010; 21(5): 1587-1597.

. Ha PT, Le TTH, Hoang TMN, Nguyen TT, Nguyen DT, Ha TMT, Pham TBH, Tran TMN, Nguyen TQ, Pham HN, Tran DL, Nguyen XP and Duong TQ. Fe3O4/O-Carboxymethyl Chitosan/Curcumin-based Nanodrug System for Chemotherapy and Fluorescence Imaging in HT29 Cancer Cell Line. Chemistry Letters; 40(11): 1264-1266.

. Smith JP, Kanekal S, Patawaran MB, Chen JY, Jones RE, Orenberg EK and Ning YY. Drug retention and distribution after intratumoral chemotherapy with fluorouracil/epinephrine injectable gel in human pancreatic cancer xenografts. Cancer chemotherapy and pharmacology. 1999; 44(4): 267-274.

. Wang F, Zhang D, Duan C, Jia L, Feng F, Liu Y, Wang Y, Hao L and Zhang Q. Preparation and characterizations of a novel deoxycholic acid–O-carboxymethylated chitosan–folic acid conjugates and self-aggregates. Carbohydrate Polymers. 2011; 84(3): 1192-1200.

. Bhattacharya D, Das M, Mishra D, Banerjee I, Sahu SK, Maiti TK and Pramanik P. Folate receptor targeted, carboxymethyl chitosan functionalized iron oxide nanoparticles: a novel ultradispersed nanoconjugates for bimodal imaging. Nanoscale. 2011; 3(4): 1653-1662.

. Yang SJ, Lin FH, Tsai HM, Lin CF, Chin HC, Wong JM and Shieh MJ. Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms. Biomaterials. 2011; 32(8): 2174-2182.

. Wang F, Chen Y, Zhang D, Zhang Q, Zheng D, Hao L, Liu Y, Duan C, Jia L and Liu G. Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan-folic acid micelles. Int J Nanomedicine. 2012; 7(145): 325-337.

. Ji J, Wu D, Liu L, Chen J and Xu Y. Preparation, evaluation, and in vitro release of folic acid conjugated O‐carboxymethyl chitosan nanoparticles loaded with methotrexate. Journal of Applied Polymer Science. 2012; 125(S2): E208-E215.

. Mansouri S, Cuie Y, Winnik F, Shi Q, Lavigne P, Benderdour M, Beaumont E and Fernandes JC. Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials. 2006; 27(9): 2060-2065.

. Kolev TM, Velcheva EA, Stamboliyska BA and Spiteller M. DFT and experimental studies of the structure and vibrational spectra of curcumin. International Journal of Quantum Chemistry. 2005; 102(6): 1069-1079.

. Zheng M, Han B, Yang Y and Liu W. Synthesis, characterization and biological safety of O-carboxymethyl chitosan used to treat Sarcoma 180 tumor. Carbohydrate Polymers. 2011; 86(1): 231-238.

. Zhang J, Rana S, Srivastava RS and Misra RDK. On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles. Acta Biomaterialia. 2008; 4(1): 40-48.

. Li H, Li Z, Zhao J, Tang B, Chen Y, Hu Y, He Z and Wang Y. (2014). Carboxymethyl chitosan-folic acid-conjugated Fe3O4@ SiO2 as a safe and targeting antitumor nanovehicle in vitro. Nanoscale research letters. 2014; 9(1): 1-11.

. Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY and Lin JK. Stability of curcumin in buffer solutions and characterization of its degradation products. Journal of pharmaceutical and biomedical analysis. 1997; 15(12): 1867-1876.

. Shen L and Ji HF. Insights into the inhibition of xanthine oxidase by curcumin. Bioorganic & medicinal chemistry letters. 2009; 19(21): 5990-5993.

. Hegyi G and Venyaminov SY. Absence of gross changes in the secondary structure of actin at GF transition. FEBS letters. 1980; 109(1): 134-136.

. Xu C, Fan Z, Chao YL, Du L and Zhang FQ. Magnetic fields of 10mT and 120mT change cell shape and structure of F-actins of periodontal ligament cells. Bioelectrochemistry. 2008; 72(1): 41-46.

. Supporting Information is also available electronically on the International Journal of Drug Delivery. Web site: http://www.arjournals.org/index.php/ijdd/issue/archive.


Refbacks

  • There are currently no refbacks.




Copyright (c)

               AR Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India

Copyright@arjournals.org (Design) 2009-2021

 

Follow @arjournals on Twitter