Targeting effect of folate on cancer cell through curcumin carrier nano-system

Ha Phuong Thu, Nguyen Hoai Nam, Le Quang Duong, Nguyen Thi Tham, Bui Thuc Quang, Ha Thi Minh Thi, Do Hai Doan, Hoang Thi My Nhung


Folate receptor (FR) is well known for its overexpression on surface of various cancer cell lines, which is identical to normal tissue. Folic-based targeting drug delivery systems, therefore, are one of the most effective targeting carriers that effectively bind to FR up-regulated cancer cells. Curcumin was used both for labeling and chemotherapy. The materials were characterized and structurally confirmed by FT-IR spectra, fluorescent images and FE-SEM images. Bioassays were conducted on HeLa and HT29 cancer cell lines after 4 and 12 hours. Results show that folic acid significantly enhanced both targeting efficiency and internalization of curcumin to FR-expressing cancer cells.


Drug delivery systems, Nanoparticle, Targeting effect, Curcumin, OCMCs, Folic acid.

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