Aripiprazole loaded PLGA nanoparticles for controlled release studies: Effect of Co-polymer ratio

A Chandra Babu, P Kumara Babu, K Sudhakar, M.C.S. Subha, K Chowdoji Rao

Abstract


Poly (lactic-co-glycolic acid) nanoparticles loaded with Aripiprazole has been developed as a new therapeutic strategy to achieve its controlled release profile suitable for parenteral administration. Nanospheres composed of different lactic/glycolic acid ratios and drug compositions were synthesized and loaded with Aripiprazole by emulsion/solvent evaporation method and subsequently characterized by particle-size distribution, scanning electron microscopy, encapsulation efficiency and in–vitro drug release studies. Specific drug-polymer interactions are engineered by optimizing the lactide to glycolide ratio (L:G ratio) and including specific polymer hydrophobicity.


Keywords


PLGA Nanoparticles, Co-polymer Ratio, Controlled drug delivery

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