Ternary Blends of some Hydrophilic and Hydrophobic Polymers in Colon Targeted Delivery of Metronidazole

Clement Jackson, Martins Emeje, Sabinus Ofoefule

Abstract


Matrix tablets were prepared using blends of xanthan gum (XG), Guar gum (GG) and ethylcellulose (EC). The polymers were combined using six different ratios; 1:1:1, 1:2:1, 1:2:2, 2:2:1, 2:1:2 and 2:1:1 to produce formulations XG1GG1EC1, XG1GG2EC1, XG1GG2EC2, XG2GG2EC1. XG2GG1EC2 and XG2GG1EC1 respectively. Metronidazole was used as the model drug. The ability of the prepared matrices to target drug release predominantly at the colon under the influence of colonic bacteria was evaluated using the dissolution medium containing 4 % caecal content. Our results show that, optimum drug release was observed with formulations XG2GG2EC1 and XG2GG1EC1 with Cmax of 60 and 76 % respectively. Significant difference (P<0.05) was observed between drug release in dissolution medium with and without rat caecal contents for the batches of Metronidazole tablets. Formulations (XG2GG2EC1 and XG2GG1EC1) followed Higuchi square roots kinetics ( r2 =0.9942) via fickian diffusion ( n < 0.45 ) and Korsemeyer model (r2 = 0.9939) via non – fickian diffusion (n > 0.45) respectively.

Key Words; matrix.guar, xanthan, ethylcellulose, metronidazole, colon delivery


Keywords


matrix.guar, xanthan, ethylcellulose, metronidazole, colon delivery

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References


J. A. Walsh. Problems in recognition and diagnosis of amoebiasis: estimation of

the global magnitude of morbidity and mortality. Rev. Infect. Dis., 1986, 8: 228-238.

Martindale. The Complete Drug Reference, 34th Ed., Sean C. Sweetman (Ed.),

The Pharmaceutical Press, 2005.

. Kotla Niranjan*, Ashwini Shivapooja, Jagadish Muthyala, Pandya Pinakin Effect of Guar Gum and Xanthan Gum Compression Coating on Release Studies of Metronidazole in Human Fecal Media for Colon Targeted Drug Delivery Systems. Asian J.Pharm.Clin.Res. 2013; 6(2); 315 - 318

.P.S. Salve.Development and in vitro evaluation colon targeted drug delivery system using natural gums. Asian J. Pharm. Res.2011 ;1 (4): 91-101

. A. D. Kajale, R.S. kamble, K.P.Giradkar, B.V. Bakde, M.A. Channawar and Dr. A.V. Chandewar . Colon Targeted Drug Delivery using Natural PolymerS.Int. J. Pharm. Res.Dev. 2010 ;292: 1-6

.Amit Kumar Panigrahi, Mathrusri.M. Annapurna and K. Himasankar. Polysaccharide Matrix Tablet for Colon Specific Drug Delivery. Int.J.Pharm.Sci. Res.2012 ;3(10) : 3842 - 3846

.B. K. Sridhar, A. Srinatha,* B. B. Zaman, and H. Ragunandan . Development and Evaluation of Microbial Degradation Dependent Compression C

oated Secnidazole Tablets for Colonic Delivery. Indian J Pharm Sci. 2011; 73(6): 641–648.

. Sinha, V. R., Mittal B. R., Bhutani, K. K., Kumria Rachna . Colonic drug delivery of 5-fluorouracil: an in vitro evaluation Int J Pharm. 2004 ; 269(1):101-108

. Clement Jackson and Sabinus Ofoefule.

Use of Xanthan Gum and Ethylcellulose in Formulation of Metronidazole for

Colon Delivery. J. chem. Pharm. Res. 2011 ; 3(2):11-20

. Cooper J and Gunn C. Powder flow and compaction. In: Carter S.J, Tutorial Pharmacy, CBS publishers, New Delhi, 1986; 211 – 233.

. Shah D, Shah Y and Rampradhan M. Development and evaluation of controlled release diltiazem hydrochloride microparticles using cross – linked polyvinyl alcohol. Drug Dev Ind Pharm.1977 ; 23: 567 – 574.

. United States of Pharmacopeia-National Formulary. USP 30 – NF 25. The Unit States Pharmacopeial Convention, Rockville, MD, 2007;Vol. 1, 226.

. Rippe E. Compression of solid and compressed dosage forms. In: Encyclopedia of pharmaceutical technology, Swarhrick, J.Marcel Dekker. Inc., New York, 1990; 149-166.

. Pharmacopoeia of India. Ministry of health and family welfare. Govt. of India, Controller of publications, New Delhi, 1996; vol.II., 736; A-80-83, 147 and 169.

. Leon Lachman, Herhert A, Liberman and Joseph L Karnig. The theory and practice of industrial pharmacy. 3rd ed. Lea and Febigen, Philadelphia, 1986; 430-456.

. Pharmacopoeia of India. Ministry of health and family welfare. Govt. of India, Controller of publications, New Delhi, 2007; vol.II, 1795.

United States Pharmacopoeial Convention (USP) 1999, USP 24- NF – 19,

Rockville, USA

Sinha, V.R., Mittal,B.R., Bhutani, K. K., Rachna Kumari . Colonic drug

Delivery of 5–fluorouracil:an in vitro evaluation. Int J.Pharm. 2004;269:101 -108

. Merchant, H. A ; Shoiab H . M ; Tazeen J ; and Yousuf R. I . A once

daily Tablet formulation and in vitro release evaluation of cepfodoxime using

Hydroxypropylmethylcellulose: a technical note: AAPS Pharm. SciTech

;7 (3 ) article 78

. Wilmington,DE. Polymer blend matrix for oral sustained drug delivery.

Pharm .tech. report 016. Hercules Incorporated, Aqualon Division.2002

.Emeje MO. Effect of Molecular size and some Hydrophobic polymers

on the sustained release performance of a gel forming polymer:M.Pharm Dissertation, University of Nigeria, Nsukka. 2005.

. Martins EMEJE, Phyllis NWABUNIKE, Yetunde ISIMI, Olobayo KUNLE, Sabinus OFOEFULE. Preparation and evaluation of colon targeted drug delivery systems for albendazole using kneading, extrusion and compaction technology. Acta Pharmaceutica Sinica 2009, 44 (10): 1152-1158]

.A.Shirwikar, Annie Shirwaikar and G.Aravina Kumar . Herbal Excipients in Novel drug Delivery systems. Indian J.Pharm.Sci. 2008 ;70 (4):415 - 422

. Gohel MC, Amin AF, Patel KV, Panchal MK . Studies in release behaviour of diltiazem HCl from matrix tablets containing (hydroxypropyl) methylcellulose and xanthan gum. Boll Chim farm. 2002 ;141; 21 - 28

. Guide for the care and Use of Laboratory animals. Eight Ed . National Academic Press. Washington D.C.2011


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