Biodegradable graft hydrogel membranes for in-vitro release studies of Levofloxacin Hemihydrate drug

MN Prabhakar, A Chandra Babu, MCS Subha, K Chowdoji Rao

Abstract


Controlled release of Levofloxacin Hemihydrate drug through Methyl Methacrylate grafted Poly (vinyl alcohol) (PVA-g-MMA) hydrogel membranes have been investigated. These graft co-polymer hydrogel membranes of various formulations were prepared using conventional solution casting method by varying, monomer, cross-linker and drug content. An attempt has been made to characterize these hydrogel membranes by various instrumental techniques like, Fourier Transform Infrared Spectroscopy (FT-IR), X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). The release patterns of the drug from the hydrogel membrane were carried out in pH 7.4 media and the samples were analysed spectrophotometrically at 294 nm wavelength on a UV Vis spectrophotometer. The mechanical properties of the hydrogel membranes were characterized by UTM. FTIR spectra of the membranes indicated complete esterification of the free carboxyl groups of Methyl Methacrylate. XRD studies indicated that the crystallinity of the membranes was mainly due to Methyl Methacrylate. The experimental results indicated that the hydrogel membrane could be tried for various biomedical applications

Keywords


Biocompatibility; Poly (Vinyl Alcohol); Methyl Methacrylate, Levofloxine Hemihydrate

Full Text:

PDF

References


Gardner C. Drug Targeting: Potentials and Limitations. In: Topics in Pharmaceutical Science, (Eds) D.D. Briemer, P. Speiser, 1983;291.

Gregoriadis G. Nature, 1977;265:407.

Gregoriadis G, Senior J, Poste G, (Eds), Targeting of Drugs with Synthetic Systems. NATO-ASI Series (No. 113), Plenum Press, NY, 1986.

Gregoriadis G, Poste G. (Eds), Targeting of Drugs, Anatomical and Physical Considerations. Plenum Press, NY, 1988.

Krishna Rao KSV, Kiran Kumar ABV, Madhusudhana Rao K, Subha MCS, Yong-Iii Lee. Polymer Bulletin 2008;61:81.

Venkata Prasad C, Sudhakar H, Yerri Swamy B, Venkata Reddy G, Reddy CLN, Prabhakar MN, Suryanarayana C, Subha MCS, Chowdoji Rao K. Journal of Applied Polymer Science 2011;121:2717.

Khanah Mokwena K, Juming Tang. Critical Reviews in Food Science and Nutrition 2012;52:640–650.

Mallapragada SK, Peppas NA. Dissolution mechanism of semicrystalline poly (vinyl alcohol) in water. J. Polym. Sci., Part B, Polym. Physics 1996;34:1339.

Paradossi G, Lisi R, Paci M, Crescenzi V. New hydrogels based on poly (vinyl alcohol). J. Polym.Sci. Part A, Polym. Chem. 1996;34:3417.

Jegal J, Lee K. Nanofilteration membranes based on poly (vinyl alcohol) and ionic polymers. J.Appl. Polym. Sci. 1999;72: 1755-1762.

Chandy T, and Sharma CP. Prostaglandin E1-immobilized poly (vinyl alcohol) -blended chitosan membranes: Blood compatibility and permeability properties. J. Appl. Polym. Sci. 1992;44:2145-2156.

Mathew J, Kodama M. Study of blood compatible polymers I. modification of poly (vinyl alcohol). Polym. J. 1992;24:31- 41.

Saraydin D, Karadag E, Oeztop N, Gueven O. Biomaterials 1994;15:917.

Rolland, Gibassier D, Sado P, Le Verge R. J. Pharm. Belg. 1986;41:83.

Kreuter J, Liehl E, Berg U, Soliva M, Speiser PP. Vaccine 1988;6:253.

Badwan AA, Abumalooh A, Sallam E, Abukalaf A, Jawan OA. Drug Dev. Ind. Pharm. 1985;11:239-256.

Arıca B, Çalı S, Ka HS, Sargon MF, Hıncal AA, Int. J. Pharm. 2002;242:267-269.

Halder A, Mukherjee S, Sa B. J. Microencapsul. 2005;22:67-80.

Sarmento B, Ferreira D, Veiga F, Ribeiro A. Carbohydr. Polym. 2006;66:1-7.

Ahmad Z, Pandey R, Sharma S, Khuller GK. Indian J. Chest. Dis. Allied. Sci. 2006;48:171-176.

Sezer AD, Akbuga J. J. Microencapsul. 1999;16:687-696.

Janes KA, Alonso MJ. J. Appl. Polym.Sci. 2003;88:2769-2776.

Yassin AEB, Alsarra IA, Al-Mohizea AM. Sci. Pharm. 2006;74:175-188.

Srinatha A, Pandit JK, Singh S. Ind. J. Pharm. Sci. 2008;70:16-21.

Badawi AA, El-Laithy HM, El Qidra RK, El Mofty H, El dally M. Pharm. Res. 2008;31:1040-1049.

Thimma RT, Tammishetti S, J. Appl. Polym. Sci. 2001;82:3084-3090.

Reddy T, Tammishetti S. J. Microencapsul. 2002;19:311-318.

Al-Saidan SM, Krishnaiah YS, Patro SS, Satyanaryana V. AAPS PharmSciTech. 2005;6:14-21.

Talukdar MM, Kinget R. Int. J. Pharm. 1995;120:63-72.

Yeole PG, Galgatte UC, Babla IB, Nakhat PD. Ind. J. Pharm. Sci. 2006;68:185-189.

Maiti S, Ray S, Mandal B, Sarkar S, Sa B, J. Microencapsul, 2007;24:743-756.

Jain S, Yadav SK, Patil UK, J.Pharm. Tech., 2008;1:374-376.

Aydin Z, Akbugˇa J, Int. J. Pharm., 1996;137:133-136.

Sriamornsak P, Nunthanid J., Int. J.Pharm., 1998;160:207-212.

Patil S, Sharma S, Nimbalkar A, Pawar A, Drug Dev. Ind. Pharm., 2006;32:315-326.

Parauvathanahalli S, Mishra RB, Acta. Pharmaceutica., 2007;57:413-427.

Dicaro S, Zocco AM, Cremonini F, Candelli M, Nista EC, Bartolozzi F, Armuzzi A, Cammarota G, Santarelli L, Gasbarrini A, Eur. J. Gastroenterol. Hepat. 2002;14(12): 1309–1312.

O’Morain C, Eur. Gastroenerol. Rev. 2005;1:56–59.

Watanabe Y, Aoyama N, Shirasaka D, Maekawa S, Kuroda K, Miki I, Kachi M, Fukuda M, Wambura C, Tamura T, Kasuga M, Digest. Liver Dis., 2003;35:711–715.

Nista EC, Candelli M, Zocco MA, Cremonini F, Ojetti V, Finizio R, Spada C, Cammarota G, Gasbarrini G, Gasbarrini A, J. Gastroenterol. 2006;101(9):1985–1990.

Levofloxacin, the American Society of Health-System Pharmacists. Retrieved 3 April 2011.

Chowdhury P, Ali MA, Journal of applied Polymer Science, 2005;97:2335.

Chowdhury P, Ali MA, Journal of Polymer Matter, 2005;22:227.

Dyer JR, Application of Absorption Spectroscopy of Organic Compounds (Prentice-hill of India Pvt. Ltd., New Delhi) 1991:36.

Williams DH, Fleming I, Spectroscopic Methods in Organic Chemistry, 4th Edition (Tata Mc Graw-Hill, New Delhi) 1988:50.

Ramesh Babu V, Krishna Rao KSV, Sairam M, Vijaya Kumar Naidu B, Hosamani KM, Aminabavi TM, J. of Appl Polym Sci, 2006;99:2671.

Krishna Rao KSV, Vijaya Kumar Naidu B, Subha MCS, Sairam M,. Aminabhavi TM, Carbohydrate Polymers, 2006;66:333.

Prasad CV, Yerriswamy B, Reddy CLN, Vara Prasad K, Sudhakar P, Subha MCS, Jung IL Song, Chowdoji Rao K, Journal of Polymer Environment, 2012;20:344.

Ritger PL, Peppas NA, J. Control. Rel. 1987;5:37.


Refbacks





Copyright (c)

               AR Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India

Copyright@arjournals.org (Design) 2009-2021

 

Follow @arjournals on Twitter