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Ion exchange resins Pharmaceutical applications and recent advancement

S V Pande, M. D Kshirsagar, A V Chandewar

Abstract


Ion exchange resins are cross-linked water insoluble polymer-carrying, ionizable functional groups. IER have received considerable attention from pharmaceutical scientists because of their versatile properties as drug delivery vehicles. Research over the last few years has revealed that IER are equally suitable for drug delivery technologies, including controlled release, transdermal, nasal, topical and taste masking. The major drawback of sustained release of extended release or extended release is dose dumping, resulting in increased risk of toxicity. The use of IER has occupied an important place in the development of controlled- or sustained-release systems because of their better drug-retaining properties and prevention of dose dumping. Synthetic ion exchange resins have been used in pharmacy and medicine for taste masking or controlled release of drug. Drug resin complexation converts drug to amorphous form leading to improved drug dissolution. Several studies have reported the use of IER for drug delivery at the desired site of action. Sulfonated and carboxylic resins with a polystyrene backbone are most widely used in clinical medicine. Chemical deterioration of the resins is the result of several different processes. The FDA has the responsibility to define conditions under which safe food additives may be used in the production and preparation of foods and beverages.


Keywords


Ion exchange resins, taste masking

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References


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