Cover Image

New generation of orodispersible tablets: recent advances and future propects.

ganesh sheshrao bangale, G V Shinde, B. Stephen Rathinaraj


Now day’s formulation research is breaking barriers of conventional methods. Today, active ingredients can be delivered with a level of convenience, performance and bioavailability never seen in the market place. Fast disintegrating or Mouth dissolving tablet (MDTs) is one such novel approach to increase consumer acceptance by virtue of rapid disintegration, self administration without water or chewing. This novel type of delivery system offers convenience for treatment-resistant population who have difficulty in swallowing unit oral dosage form, namely Tablets and Capsules. These formulations are particularly beneficial to pediatric and geriatric patients. It is estimated that 50 % of the population is affected by dysphagia which results in high incidence of non-compliance and ineffective therapy. The aim of this article is to review the ideal properties, significance, characteristics, limitation, choice of drug candidates, challenges in formulation, approaches for preparation of MDTs, Patented technologies on MDTs, Suitable drug candidates for MDTs, Marketed product of MDTs, and Evaluation tests of MDTs


Fast disintegrating, Mouth Dissolving Tablet, Dysphagia.

Full Text:




Shyamala B, Narmada GY. Rapid dissolving tablets: A Novel Dosage Forms. The Indian Pharmacist (2002); 13(8) : 09-12.

Porter SC. Novel drug delivery: Review of Recent Trends with oral Solid Dosage Forms. American Pharm. Rev. (2001); 85:28-35.

Bradoo R, Shahani S, Deewan B, Sudarshan S. Orally Disintegrating Drug Delivery System. J Am. Med. Assoc. India (2001) ; 4(10):27-31.

Bi YX, Sunada H, Yonezawa Y, Danjo K.Evaluation of Rapidly Disintegrating Tablets Prepared by a Direct Compression Method .Drug Dev Ind Pharm (1999) ; 25:571-81.

Harmon TM. Orally Disintegrating Tablets: A Valuable Life Cycle Management Strategy”. Pharmaceutical Commerce, March (2007), available online

Shukla D, Chakraborty S, Mouth Dissolving Tablets I: An Overview of Formulation Technology, Sci Pharm. (2009) ; 76; 309–326.

Patel P B, Fast Dissolving Drug Delivery Systems:, (2006) ; 4 (4):1-7

Anon et al. Flavors and Flavoring. Int J Pharm Compounding; (1997), 1: 90-92.9.

Harmon TM. Beyond the First Generation of Orally Disintegrating Tablets. Emerging Technology. Tablets and Capsules, 3rd Sep (2006).

Dobetti L. Fast Melting Tablets: Developments and Technologies: Pharmaceutical Technology. Drug Delivery.(2001) : 44‐50.

Technology Catalysts International, “Oral Fast‐Dissolving Drug Delivery: Technologies, Market Analysis, & Business Opportunities.” August (2003).

Hamilton E, Lutz E.Orally Disintegrating tablets. Drug Delivery Technology. January (2005).

Tanmoy ghosh, Amitava ghosh. A Review on New Generation Orodispersible Tablets and its Future Prospective. Int. J.Pharm. Sci, (2011) ; 3,(1) :1-7

Wagh et al. Techniques used in orally disintegrating drug delivery system. International Journal of Drug Delivery. (2010); 2:98-107

Gohel M, Patel M, Agarwal R. Formulation Design and Optimization of Mouth Dissolving Tablets of Nimesulide using Vacuum Drying Technique. AAPS Pharm. Sci Tech.(2004); 5(3): 36.

Nail SL, Galtin LA. Freeze drying: Principles and Practices. In: Pharmaceutical Dosage Forms- Parenteral Medication, (1993) :2nd edn. Marcel Dekker Inc, New York, Vol. 2, p.n.-168.

Adel M, Semreen MK, Oato KM et al. Superdisintegrants for Solid Dispersion to Produce Rapidly Disintegrating Tenoxicam Tablets via Camphor Sublimation. Pharm.Tech.(2005) 13(4):241-247.

Kuchekar SB, Badhan CA, Mahajan SH. Mouth Dissolving Tablets: A Novel Drug Delivery System. Pharma Times. (2003) ; 35:7.

Remon JP, Corveleyn S. Freeze Dried Disintegrating Tablets. United States Patent 6,010,719. 4th January (2000).

Roser BJ, Blair J. Rapidly Soluble Oral Dosage Forms, Methods of Making Same and Composition there of. United States Patent 5,720,974. 9th June (1998).

Koizumi KI, Matsui J, Kaneda Y. New Methods of Preparing High Porosity Rapidly Saliva Soluble Compressed Tablets Using Mannitol with Camphor, a Subliming Material. Int. J Pharm. (1997) ;152: 127.

Makino T, Yamada M, Kikuta JI Fast Dissolving Tablets and its Production. United States Patent 5,720,974. 24th February 1998.Drug Delivery Technologies. May 2001. Technical Bulletin. Accessed February 2007.

Van Scoik KG. Solid Pharmaceutical Dosage in Tablet Triturates Form and Method of Producing the same. United States Patent 5,082,667. 21st January (1992).

Masaki K 1995. Intra-buccally Disintegrating Preparation and Production thereof. United States Patent 5,466,464. 14th November (1995).

Pebley WS, Jagar NF, Thomnson SJ. Rapidly Disintegrating Tablets. United States Patent 5,298,261. 29th March (1994).

Allen LV, Wang B, Davies JD . Rapidly Dissolving Tablets. United States Patent 5,807,576. 15th September (1998).

Wagh VD, Ghadlinge SV. A Review on Taste Masking Methods and Techniques in Oral Pharmaceuticals: Current Perspectives. Journal of Pharmacy Research.(2009), 2(6):1049-1054.

Allen LV, Wang B . Particulate Support Matrix for Making Rapidly Dissolving Tablets. United States Patent 5,595,761. 21st January (1997).

Dobetti L. Fast‐ Melting Tablets: Developments and Technologies: Pharmaceutical Technology. Drug Delivery( 2001) : 44‐50.

Kaushik D, Dureja H, Saini TR. Orally Disintegrating Tablets: An Overview of Melt‐in Mouth Tablet Technologies and Techniques. Tablets /Capsules (2004); 2: 30‐6.

Rish RK. A review on fast dissolving tablets techniques. The Pharma Review (2004); 2: 32.

Adel M, Semreen MK, Qato KM, et al. Fast Dissolving Dosage Forms‐.Technique. Pharm Tech (2005); 2: 68‐75.

Deshmukh K.R.Patel P.A Review on Mouth Dissolving Techniques.Int.J.of Ayurveda and Pharmacy.(2011);2(1): 66-74

Pfista WR, Gosh TK. Orally disintegrating tablets. Pharma Tech Oct 2 (2006).(PATENT)

Sreenivas SA, Dandagi PM, Gadad AP, Godbloe AM,. Orodispersible Tablets: New-Fangled Drug Delivery Systems – A Review. Indian J. Pharm. Educ. Res. (2005); 39(4):177-81.

FDA, Electronic Orange Book: Approved drug products with therapeutics. http;// Accessed March (2007).

Lachman L, Liberman H, Kanig J, The Theory and Practice of Industrial Pharmacy, 3rd edn., Varghese Publishing House, Mumbai, (1987): 297.

Khan S, Kataria P, Nakhat P, Yeole P, Taste Maskingof Ondansetron hydrochloride by Polymer Carrier System and Formulation of Rapid Disintegrating Tablets. AAPSPharm.Sci.Tech.; (2007), 8(2): 46.

Morita Y, Tsushima Y, Yasui M, Termoz R, Ajioka J, Takayama K. Evaluation of the Disintegration Time of Rapidly Disintegrating Tablets via a Novel Method Utilizing a CCD Camera. Chem. Pharm. Bull., (2002), 50(9) :1181‐1186

Kaushik, D, Dureja, H, Saini, T. R., Mouth Dissolving Tablets: A Review. Indian Drugs,

( 2004), 41(4):187-193.

Wilson CG, Washington N, Peach J, Murray GR, Kennerley J. The Behaviour of a Fast Dissolving Dosage Form (Expidet) followed by gammascintigraphy. Int J Pharm 40(1–2): 1987, 119–123.

Marshall K .In: Theory and Practice of Industrial Pharmacy, 3rd edn. (Lachman, Leon, Liberman HH, Kanig JL (Eds) Varghese Publishing hose, (1987).Mumbai, p-67-71.

Bandari S, Gannu R, Orodispersile Tablets: An Overview, Asian Journal of Pharmaceutics, (2008) ; 2-10.

Chang RK, Guo X, Burnside BA, Couch RA. Fast dissolving tablets. Pharma. Tech (2000); 24(6): 52‐8.

Bradoo R, Shahani S, Poojary S, Deewan B, Sudarshan S. JAMA India (2001); 4(10): 27‐31.

Bhaskaran S, Narmada G V. Rapid dissolving tablet A novel dosage form Indian Pharmacist (2002) ; 1(2): 9‐12.


  • There are currently no refbacks.

Copyright (c)

              AR Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India (Design) 2009-2021


Follow @arjournals on Twitter