Preparation and In-Vitro Evaluation of Sustained-Release Matrix Tablets of Diltiazem

P. Khemariya, A.K. Jain, M. Bhargava, S.K. Singhai, S. Goswami, R. Goswami


The purpose of the present research work was develop once-daily sustained-release matrix tablet containing water-soluble drug (Diltiazem) that is a novel calcium channel blocker used in cardiovascular diseases, by utilizing a combination of Hypromellose (HPMC), Eudragit with different grades and finally milled Ethyl cellulose. Tablets were prepared by the wet granulation method. The prepared granules and tablets were evaluated based on a range of parameters and in vitro drug release profile. Lastly, tablets shown approx 92%, 97% and 99 % drug release at the last dosing interval.

Keywords:- Sustain release; Diltiazem;HPMC


ustain release; Diltiazem;HPMC

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