Anticancer, antioxidant and antimicrobial activities of Suaeda fruticosa related to its phytochemical screening

Sami Ullah, Asghari Bano, Sisay Girmay, Ghee Tan


Concerning anticancer evaluation of methanolic extract of Suaeda fruticosa arial parts demonstrated the utmost anticancer activity with IC50 value of 50 μg/ml against human lung carcinoma (LU-1), the same extract displayed a preeminent activity with IC50 ≥ 50 μg/ml against hormone dependent prostrate carcinoma (LnCaP). The analyzed root extract exhibited IC50 ≤ 65 μg/ml against hormone dependent prostrate carcinoma (LnCaP) whereas, the same extract demonstrated IC50 ≤ 55 μg/ml against human lung carcinoma (LU-1). The highest content of total phenolic (0.52-0.67 mg gallic acid equiv./g) and total flavonoids (0.44 mg/g D/W) content was detected in the arial part of Suaeda fruticosa.  MIC value of 50-85 μg ml−1 has been observed gainst Aspergillus fumigates, Aspergillus niger, Fusarium solani and Mucor sp in comparision with 1-2.5μg/ml of Terbinafine used as a standard fungicide. MIC value of 80 μg/ml and 35 μg ml−1 of Suaeda fruticosa arial parts and root extract against bacterial pathogen Klebsiella pneumonia and 50 and 90 μg ml−1 against Enterococcus has been measured. DPPH radical scavenging activity of Suaeda fruticosa with IC50 values of ≤ 100 μg/ml and ≤ 50 μg ml−1 was observed whereas, hydrogen peroxide scavenging activity with IC50 values of ≤ 12.5 μg/ml for arial parts and ≤ 25 μg ml−1 for the root extract of Suaeda fruticosa has been shown with galllic acid (R2= 0.819) and ascorbic acid (R2= 0.728). These data suggested that the methanolic extract of Suaeda fruticosa could be potential candidates for natural antioxidants and anticancer.

The findings demonstrated the remarkable potentiality of Suaeda fruticosa as valuable source of antioxidant and anticancer capacities.


Suaeda fruticosa, Human lung carcinoma, Hormone dependent prostrate carcinoma, DPPH

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Ksouri, Oueslati, Samia; Riadh; Falleh, Hanen; Pichette, Andre; Abdelly, Chedly; Legault, Jean. Phenolic content, antioxidant, anti-inflammatory and anticancer activities of the edible halophyte Suaeda fruticosa Forssk. Food chemistry. 2012. 943-947(2).

Oueslati, Samia; Trabelsi, Najla; Boulaaba, Mondher; Legault, Jean; Abdelly, Chedly; Ksouri, Riadh. Evaluation of antioxidant activities of the edible and medicinal Suaeda species and related phenolic compounds. Industrial Crops and Products. 2012. 513-518(1).

Bennani-Kabchi N; el Bouayadi F; Kehel L; Fdhil H; Marquie G. Effect of Suaeda fruticosa aqueous extract in the hypercholesterolaemic and insulin-resistant sand rat. Therapie. 1999. 725-730(6).

Saidana, Dhouha; Mahjoub, Samia; Boussaada, Olfa; Chriaa, Jihane; Mahjoub, Mohamed Ali; Cheraif, Imed; Daami, Majda; Mighri, Zine; Helal, Ahmed Noureddine. Antibacterial and antifungal activities of the essential oils of two saltcedar species from Tunisia. Journal of American oil Chemist Society. 2008. 817-826(9).

Samiullah and Asghari bano. In vitro inhibition potential of four chenopod halophytes against microbial growth. special issue, december, pak. j. bot.,2011. 43: 115-119.

Wagner H, Bladt S, Zgainski EM. Plant drug analysis. Berlin: Springer; 1984.

Trease GE, Evans WC. Pharmacognosy. 12th ed. London: ELBS Publication; 1985.

Chen BH, Li SH, Lin JX, Zhuang HR. J Fujian Normal University 2003; 19:86.

Liu X, Ardo S, Bunning M, Parry J, Zhou K, Stushnoff C, LWT 2007; 40:552.

Van-Burden T.P, Robinson WC. Formation of complexes between protein and tannin acid. J. Agric Food Chem. 1981. 1: 77-82.

Sakanaka, S., Y. Tachibana and Y. Okada. Preparation and antioxidant properties of extracts of Japanese persimmon leaf tea (kakinoha-cha). Food Chem. 2005, 89: 569-575.

Harborne. J. B. “Phytochemical methods, London. Chapman and Hall Ltd, 1973. 49-188.

Obadoni, B.O, Ochuko PO. Phytochemical studies and Comparative efficacy of the crude extracts of some homeostatic plants in Edo and Delta States of Nigeria. Global J. Pure Appl. Sci. 2001. 8:203-208.

Carron, E.A, J.M. Maran, L. Montero, A. Fernandozalgo and A.Dominguez. Antimicrobial properties of some extracts obtained from some Mediterranean plants of medicinal value. Plantes Medicinales et Phytotherapie, 1987, 21: 195-202.

Washington, J.A. and V.L. Sutter. 1980. “Dilution susceptibility test: agar and macro-broth dilution procedures, In: E.H. Lennette, A. Balows, WJ. Hausler Jr., and J.P. Truant (Ed,).

Liu X, Ardo S, Bunning M, Parry J, Zhou K, Stushnoff C, LWT 2007; 40:552.

Wang TC, Ti MC, Lo SC, Yang CC. Fitoterapia 2007; 78:248.

Marino SD, Gala F, Borbone N, Zollo F, Vitalini S, Visioli F, et al. Phytochemistry 2007;68:1805.

Oktay, M., Gulcin, ˙I., Kufrevioglu, o.i., Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts. Lebensmittel-Wissenchaft und Technologie. 2003. 36, 263–271.

Ruch, R.J., Cheng, S.J., Klaunig, J.F., 1989. Prevention of cytotoxicity and inhibition of intracellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis 10, 1003–1008.

Chung, Y.C, Chang C.T, Chao WW, Lin CF, Chou ST (2002). Antioxidative activity and safety of the 50% ethanolic extract from red bean fermented by Bacillus subtilis IMR-NK1. J. Agric. Food Chem., 50: 2454-2458.

Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Boskesch H, Kenney S, Boyd MR. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990; 82: 1107-1112.

Rubinstein LV, Shoemaker RH, Paull KD, Simon RM, Tosini S, Skehan P, Scudiero DA, Monks A, Boyd MR. Comparison of in vitro anticancerdrug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst 1990; 82: 1113-1118 PubMed.

Zhang HJ, Tamez PA, Hoang VD, Tan GT, Hung NV, Xuan LT, Huong LM, Cuong NM, Thao DT, Soejarto DD, Fong HHS, Pezzuto JM. Antimalarial compounds from Rhaphidophora decursiva. J Nat Prod 2001; 64: 772-777 PubMed.

Espin JC, Garcia CMT, Tomas BFA (2007). Nutraceuricals: facts and fiction. Phytochemistry, 2007. 68: 2986-3008.

Lee YR, Woo KS, Kim KJ, Son JR, Jeong HS. Antioxidant activities of ethanol extracts from germinated specialty rough Rice. Food Sci. Biotechnol. 2007. 16(5): 765 – 770.

Shimada K, Fujikawa K, Yahara K, Nakamura T. Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion. J. Agric. Food Chem. 1992 40: 945–948.


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