Anthelminthic activity of Lavandula angustifolia Hidcote extracts using Pheretima posthuma

SARNIM S, JIGNESH S, SANJAY S T, ROSHAN A, VEDAMURTHY A B, KRISHNA V, JOY HARRIS HOSKERI

Abstract


In the present investigation, the in vitro anthelminthic activity of Lavandula angustifolia Hidcote extracts was carried out against Indian adult earthworm Pheretima posthuma. Piperazine citrate was used as the standard reference and normal saline as the control. Five different concentrations (2.5, 5.0, 7.5, 10.0 and 12.5 mg/ml) of chloroform and methanol extracts were used to determine their effect as time taken for paralysis (vermifuge) and time for death (vermicidal activity) of the worms. Both the extracts showed significant action in paralyzing and also killing the earthworms in a dose dependant manner. Among both the extracts, chloroform extract showed significant anthelminthic activity. Among the various concentrations of chloroform and methanol extracts, 12.5 mg/ml showed efficient anthelminthic activity. On the basis of these observations, we conclude that both extracts possess potential anthelminthic property and also suggest that further investigations on identification of active principles, standardization of dose and toxicity studies of this plant for drug development need to be carried out.

 


Keywords


Lavandula angustifolia Hidcote, Anthelminthic activity, Pheretima posthuma, Piperazine citrate, Methanol extract, Chloroform extract.

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References


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