The Medicinal Properties of Paullinia pinnata Linn. Leaves

Oluwatoyin Adenike Adeyemo-Salami

DOI: http://dx.doi.org/10.5138/09750185.2376

Abstract


Paullinia pinnata is a plant introduced to tropical Africa and has been reported to be useful in folkloric medicine. Different medicinal potentials of the leaves have been investigated some of which have corroborated reports in traditional medicine. Compounds have been isolated from extracts of the leaves which have been shown to have medicinal value. These compounds are from different classes of secondary metabolites including tannins, flavonoids and alkaloids. Fatty acids have also been shown to be present. This report is set to enumerate the traditional use of the leaves of P.pinnata and research findings already documented.


Keywords


Paullinia pinnata leaves, folkloric medicine, scientific investigations, isolated compounds

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References


Okoli RI, Aigbe O, Ohaju – Obodo JO, Mensah J.K. Medicinal herbs used for managing some common ailments among Esan people of Edo state, Nigeria. Pak J Nutr. 2007; 8: 490 - 496. 2. Ogbonnia SO, Odiamegwu OI, Enwuru VN. Evaluation of hypoglycaemic and hypolipidemic effects of aqueous ethanolic extracts of Treculia africana Decne and Bryophyllum pinnatum Lam. and their mixture on streptozotocin (STZ) – induced diabetic rats. Afr. J. Biotechnol. 2008; 7: 2535 – 2539. 3. Burkill HM. The useful plants of West Tropical Africa. Families S-Z, Vol. V. Kew: Royal Botanic Gardens; 2000. 4. Ikhane D, Banwo K, Omotade O, Sanni A. Phytochemical and antimicrobial activities of methanolic extract of Paullinia pinnata leaves on some selected bacterial pathogens. J. Herbs Spices Med Plants. 2015; 1: 59 – 74. 5. Akinyemi KO, Oladapo O, Okwara CE, Ibe CC, Fasure KA. Screening of crude extracts of six medicinal plants used in South-West Nigeria unorthodox medicine antimethicillin resistant Staphylococcus aureus activity. BMC Complimen. Altern. Med. 2005; 5: 1 – 7. DOI: 10 1186/1472-6882-5-6. 6. Osarenmwinda IP, Omonkhelin JO, Ejiro D. Anti- diarrhoeal activity of the methanolic extract of the leaves of Paullinia pinnata Linn. (Sapindaceae). Internet Journal of Health. 2009; 9(1) DOI: 10.5580/10d7. 7. Chhabra SC, Makuna RL, Mshiu EN. Plants used in traditional medicine in Eastern Tanzania. V. J. Ethnopharmacol. 1991; 33: 143-157. 8. Huang Q, Lu GH, Shen HM, Chung MC, Ong CN. Anti – cancer properties of anthraquinines from Rhubarb. Med. Res. Rev. 2007; 27: 609 – 630. 9. Agyare C, Asase A, Lechtenberg M, Niehues M, Deters A, Hensel A. An ethnopharmacological survey and in-vitro confirmation of ethnopharmacological use of medicinal plants used for wound healing in Bosomtwi-Atwima-Kwanwoma area, Ghana. J. Ethnopharmacol. 2009; 125: 393- 403. 10. Focho DA, Nkeng EA, Lucha LF, Ndam WT, Afegenui A. Ethnobotanical survey of plants used to treat diseases of the reproductive system and preliminary phytochemical screening of some species of Malvaceae in Ndop Central Sub-division, Cameroon. J. Med. Plant. Res. 2009; 3: 301-314. 11. Addo-Fordjour P, Anning AK, Belford EJ, Akonnor D. Diversity and conservation of medicinal plants in the Bomaa community of the Brong Ahafo region, Ghana. J. Med. Plant Res. 2008; 2: 226-233. 12. Adeyemo – Salami OA, Makinde JM. Acute and sub-acute toxicity studies of the methanol extract of the leaves of Paullinia pinnata (Linn.) in Wistar albino mice and rats. Afr. J. Med. Med. Sci. 2013; 42: 81- 90. 13. Nnah IJ, Uche EE. Effect of ethanol extract of Paullinia pinnata leaves on the blood pressure of cats. IJMPS. 2014; 4: 21-26. 14. Lunga PK, Nkodo JM, Tamokou JD, Kuiate J-R, Gatsing D, Tchoumboue J. Post-treatment evaluation of the side effects of methanol leaf extract from Paullinia pinnata (Linn.), an antityphoid plant. Pharmacologia. 2015; 6: 264- 272. 15. Annan K, Houghton PJ. Antibacterial activity of Paullinia pinnata extracts. Abstracts of Ninth International Congress of the International Society of Ethnobiology, Canterbury. [abstract] 2004. 16. Roger T, Pierre-Marie M, Igor VK, Patrick VD. Phytochemical screening and antibacterial activity of medicinal plants used to treat typhoid fever in Bamboutos division, West Cameroon. J. Appl. Pharm. Sci. 2015; 5: 34- 49. 17. Broadbent JL. Cardiotonic action of two tannins. Br. J. Pharmacol. 1962; 18: 167 – 174. 18. Maje IM, Anuka JA, Hussain IM, Katsayel UA, Varo AH, Magaji MG, Jamilu Y, Sani M, Musa Y. Evaluation of the anti-malarial activity of the ethanolic leaves extract of Paullinia pinnata Linn. (Sapindaceae). Niger J Pharm Sci. 2007; 6: 67 – 72. 19. Adeyemo – Salami OA, Farombi EO, Ademowo OG. An investigation into the antimalarial effect of methanolic extract of Paullinia pinnata leaves in Plasmodium berghei infected mice and course of infection. Afr. J. Med. Med. Sci. 2014; 43 (Suppl): 93-100. 20. Ior LD, Uguru MO, Olotu PN, Ohemu TL, Ukpe A. Evaluation of analgelsic and anti – Inflammatory activities and phytochemical screening of the leaf extract of Paullinia pinnata (sapindacae). J. Chem. Pharm. Res. 2011; 3: 351 – 356. 21. Patience DAT, Brice KA, Julia BEA, Desire DDP, Pierre K, Theophile, D. Subchronic and chronic anti-inflammatory properties of the aqueous extract of dried leaves of Paullinia pinnata (Sapindaceae) Linn. Res. J. Pharm Biol. Chem. Sci. 2017a; 8: 586- 596. 22. Patience DAT, Brice KA, Julia BEA, Desie DDP, Pierre K, Theophile D. Analgesic and acute inflammation properties of the aqueous extract of dried leaves of Paullinia pinnata (Sapindaceae) Linn. International Journal of Phytomedicine. 2017b; 9: 490. doi-10.5138/09750185.2115. 23. Aliyu M, Anuka JA, Yaro H, Magaji MG. Evaluation of the anxiolytic effect of methanolic leaves extract of Paullinia pinnata Linn. in mice. Br. J. Pharm. Res. 2014; 4:1638-1646. 24. Zamble AM, Carpentier M, Kandoussi A, Sahpaz S, Petrault O, Onk T, Hennuyer N, Fruchart J, Staels B, Bordet R, Duriez P, Bailleul F, Martin – Nizard F. Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms. J. Cardiovasc Pharmacol. 2006; 47: 599-608. 25. Lunga PK, Tamokou J de D, Fodouop SP, Kuiate J-R, Tchoumbone J, Gatsing D. Antityphoid and radical scavenging properties of the methanol extracts and compounds from the aerial part of Paullinia pinnata. Springerplus 2014a; 3: 302. DOI: 10.1186/2193 – 1801 – 3 – 302. 26. Jimoh FO, Sofidiya MO, Afolayan AJ. Antioxidant properties of the methanol extracts from the leaves of Paullinia pinnata. J. Med. Food. 2007; 10: 707 – 711. 27. Tamokou JD, Chouna JR, Fischer- Fodor E, Chereches G, Barbos O, Damian G, Benedec D, Duma M, Efouet AP, Wabo HK, Kuiate JR, Mot A, Silaghi-Dumitrescu R. Anticancer and antimicrobial activities of some antioxidant-rich Cameroonian medicinal plants. PLoS One. 2013; 8: e55880. DOI:10.1371/journal.pone.0055880. 28. Adeyemo – Salami OA, Ewuola EO. Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in Wistar albino rats. Phcog Res. 2015; 7: S34 – S38. 29. Salami OA, Fafunso MA. Phytotoxic activity of methanol leaves extract of Paullinia pinnata (Linn.). Niger J Nat Prod Med. 2016; 20: 1-3. 30. Melendez PA, Capriles VA. Molluscicidal activity of plants from Puerto Rico. Ann. Trop. Med. Parasitol. 2002; 96: 209 – 218. 31. Fred-Jaiyesimi AA, Anthony O. Larvicidal activities of the extract and fractions of Paullinia pinnata Linn. leaf. Phcog. Comm. 2011; 1: 37- 40. 32. Maiha BB, Magaji MG, Yaro AH, Hamza AH, Ahmed ST, Magaji RA. Anticonvulsant studies on Cochlospermum tinctorium and Paullinia pinnata extracts in laboratory animals. Niger J Pharm Sci. 2009; 18: 102-108. 33. Lunga PK, Tamokou J de D, Gerald NT, Donatien G, Kuiate J.R. Antibacterial and antioxidant properties of Paullinia pinnata (Sapindaceae) and Ficus thonningii (Moraceae) methanol crude bark extracts. 2011. Website: jrkuiate.blogspot.com.ng/2011/06/nbacterial-and-antioxidant-properties.htm. (accessed 8 January 2014). 34. Iful ES: Studies in the anti - venom activities of the aqueous extracts of Paullinia pinnata and Datarium microcarpum against Echis carinatus (Carpet viper) venom. Ph. D. Thesis. University of Jos, Department of Pharmacology; 2008. 35. Spiegler V, Liebau E, Peppler C, Raue K, Werne S, Strube C, Heckendorn F, Agyare C, Stark T, Hofmann T, Hensel A. A hydroalcoholic extract from Paullinia pinnata L. root exerts anthelmintic activity against free-living and parasitic nematodes. Planta Med. 2016; 82: 1173-1179. 36. Ayim JA, Bayor MT, Phillips RM, Shnyder SD, Wright CW. The eveluation of selected Ghanaian medicinal plants for cytotoxic activities. JST. 2007; 27: 16-22. 37. Annan K, Houghton PJ, Govindarajan R. In-vitro and in-vivo wound healing actions of Paullinia pinnata L. Planta Med. 2007; 73: 463. D01: 10.1055/s-2007 -987243. 38. Annan K, Govindarajan R, Kisseih E. Wound healing and cyto protective actions of Paullinia pinnata L. Phcog. J. 2010; 2: 345 – 350. 39. Annan K, Gbedema S, Adu F. Antibacterial and radical scavenging activity of fatty acids from Paullinia pinnata L. Phcog. Mag. 2009a; 5(Suppl S2): 119 – 123. 40. Annan K, Adu F, Gbedema SY. Friedelin: A bacterial resistance modulator from Paullinia pinnata L. JST (Ghana). 2009b; 29: 152-159. 41. Imade FN, Nosakhare NG, Mensah JK. 2015. Phytochemical and antibacterial properties of leaf, stem and root of Paullinia pinnata Linn. Nigerian annals of natural sciences 15: 79-84. 42. Lunga PK, Qin XJ, Yang XW, Kuiate JR, Duz Z, Gatsins D. Antimicrobial steroidal saponin and oleanane – type triterpenoid saponins of Paullinia pinnata. BMC Complement Altern Med. 2014b; 14: 369. DOI: 10.1186/1472 – 6882 – 14 – 369. 43. Lasisi AA, Ayinde BW, Adeleye AO, Onocha PA, Oladosu IA, Idowu P.A. New triterpene isovanniloyl and antibacterial activity of constituents from the roots of Paullinia pinnata Linn. (Sapindaceae). J. Saudi Chem. Soc. 2015; 19: 117-122. 44. Jackson N, Annan K, Mensah AY, Ekuadzi E, Mensah ML, Habtemariam S. A novel triterpene from the roots of Paullinia pinnata: 6α-(3′-Methoxy-4′-hydroxybenzoyl)-lup-20(29)-ene-3-one. Nat. Prod. Commun. 2015; 10: 563- 564. 45. Abourashed EA, Toyang NJ, Choinski Jr J, Khan IA. Two new flavone glycosides from Paullinia pinnata. J. Nat. Prod. 1999; 62: 1179 – 1181. 46. Yusuf AZ, Zakir A, Shemau Z, Abdullahi M, Halima S.A. Phytochemical analysis of the methanol leaves extract of Paullinia pinnata Linn. J. Pharmacognosy Phytother. 2014; 6:10-16. 47. Miemanang RS, Krohn K, Hussain H, Dongo E. Paullinoside A and Paullinomide A: A new cerebroside and a new ceramide from the leaves of Paullinia pinnata. Z. Naturforsch. 2006; 61b: 1123 – 1126. 48. Dongo E, Hussain H, Miemanang SR, Tazwo D, Schulz B, Krohn K. Chemical constituents of Klainedoxa gabonenses and Paullinia pinnata. Rec. Nat. Prod. 2009; 3: 165 – 169. 49. Frimpong-Manso S, Magnus-Aryitey GT, Hevi D, Dombi G, Nyarko AK, Boamah D, Awan M. Bioinorganic elemental content of the Ghanaian aphrodisiac medicinal plant, Paullinia pinnata Linn. (Sapindaceae). Afr. J. Pharm. Pharmacol. 2016; 10: 206- 211.


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