Anti-α-glucosidase and antiglycation activities of galls from Guiera senegalensis J.F. Gmel (combretaceae)

Pierre Alexandre Eric Djifaby SOMBIE, Rahman M HAFIZUR, Moussa COMPAORÉ, Martin KIENDREBEOGO, Muhammad Iqbal CHOUDHARY, Odile Germaine NACOULMA

Abstract


The hypoglycemic activity of Guiera senegalensis used in Burkinabe folk medicine has been already reported. The aim of this study was to investigate the in vitro antidiabetic activity from galls of G.senegalensis. The extracts and methanol fractions from galls of G. senegalensis showed strong α-glucosidase inhibitory activity compared with acarbose. The ethyl acetate fraction from methanol extract (EA/ME) showed potent antiglycation activity in an in vitro assay system. The galls did not show inhibition activity against α-chymotrypsin. The α-glucosidase inhibitory activity along with its antiglycation activity may open a new perspective for the use of G. senegalensis for the diabetic subject. The data suggests that consumption of G senegalensis galls as an infusion or in food and pharmaceutical preparations may be useful for the management of diabetes and its complications.


Keywords


Guiera senegalensis, Galls, α-Glucosidase; Antiglycation, α-chymotrypsin

References


George C, Lochner A, Huisamen B. The efficacy of Prosopis glandulosa as antidiabetic treatment in rat models of diabetes and insulin resistance. J. Ethnopharmacol. 2011; 137: 298–304. https://doi.org/10.1016/j.jep.2011.05.023

Sabiu S, O’Neill F.H, Ashafa AOT. Kinetics of α-amylase and α-glucosidase inhibitory potential of Zea mays Linnaeus (Poaceae), Stigma maydis aqueous extract: An in vitro assessment. J. Ethnopharmacol. 2016. http://dx.doi.org/10.1016/j.jep.2016.02.024

Proença C, Freitas M, Ribeiro D, Oliveira EFT, Sousa JLC, Tomé SM, Ramos MJ, Silva AMS, Fernandes PA, Fernandes E. α -Glucosidase inhibition by flavonoids : an in vitro and in silico structure – activity relationship study. J. Enzyme Inhib. Med. Chem.2017; 32 (1): 1216–1228. Doi: 10.1080/14756366.2017.1368503

Yin Z, Zhang W, Feng F, Zhang Y, Kang W. α -Glucosidase inhibitors isolated from medicinal plants. Food Sci. Hum. Wellness. 2014; 3: 136–174. http://dx.doi.org/10.1016/j.fshw.2014.11.003

Jo S-H, Cho C-Y, Lee J-Y, Ha K-S, Kwon Y-I, Apostolidis E. In vitro and in vivo reduction of post-prandial blood glucose levels by ethyl alcohol and water Zingiber mioga extracts through the inhibition of carbohydrate hydrolyzing enzymes. BMC Complement. Altern. Med. 2016; 16 (111). doi:10.1186/s12906-016-1090-4.

Lin L, Dong Y, Zhao H, Wen L, Yang B, Zhao M. Comparative evaluation of rosmarinic acid, methyl rosmarinate and pedalitin isolated from Rabdosia serra (MAXIM.) HARA as inhibitors of tyrosinase and α-glucosidase. Food Chem. 2011; 129: 884–889. https://doi.org/10.1016/j.foodchem.2011.05.039

Behl T, Kaur I, Kotwani A. Implication of oxidative stress in progression of diabetic retinopathy. Surv. Ophthalmol. 2016; 61: 187–196. doi: http://dx.doi.org/10.1016/j.survophthal.2015.06.001

Ademiluyi AO and Oboh G. Soybean phenolic rich extracts inhibit key-enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting enzyme) in vitro. Exp. Toxicol. Pathol. 2013; 65: 305–309. https://doi.org/10.1016/j.etp.2011.09.005

Wang SY, Camp MJ, Ehlenfeldt MK. Antioxidant capacity and α-glucosidase inhibitory activity in peel and flesh of blueberry (Vaccinium spp.) cultivars. Food Chem. 2012; 132 : 1759–1768. https://doi.org/10.1016/j.foodchem.2011.11.134

Sombie PAED, Hilou A, Mounier C, Coulibaly AY, Kiendrebeogo M, Millogo JF, Nacoulma O.G. Antioxidant and anti-inflammatory activities from galls of Guiera senegalensis J.F. Gmel (Combretaceae). Research Journal of Medicinal Plant. 2011; 5: 448–461. DOI: 10.3923/rjmp.2011.448.461

Bouchet N, Levesque J, Blond A, Bodo B, Pousset J-L. 1,3-di-O-galloylquinic acid from Guiera senegalensis. Phytochemistry. 1996; 42: 189–190. https://doi.org/10.1016/0031-9422(95)00925-6

Elrahman AOF, Abuelgasim AI, Galal M. Toxicopathological effects of Guiera senegalensis extracts in wistar albino rats. Journal of Medicinal Plants Research .2008; 2 (1) : 001–004

Kankara SS, Mustafa M, Ibrahim HM, Nulit R, Go R. Effect of drying methods , solid-solvent ratio , extraction time and extraction temperature on phenolic antioxidants and antioxidant activity of Guiera senegalensis J.F.Gmel ( Combretaceae ) Leaves Water Extract. American Journal of Phytomedicine and Clinical Therapeutics. 2014; 12: 1378-1392

Choudhary MI, Shah SAA, Rahman A, Khan S-N, Khan MTH. Alpha-glucosidase and tyrosinase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones. Steroids. 2010; 75 (12): 956–966. doi: 10.1016/j.steroids.2010.05.017

Pu J, Peng G, Li L,Na H, Liu Y, Liu P. Palmitic acid acutely stimulates glucose uptake via activation of Akt and ERK1/2 in skeletal muscle cells. J. Lipid Res. 2011; 52 (7): 1319–1327. doi: 10.1194/jlr.M011254

Fouotsa H, Lannang AM, Mbazoa C D, Rasheed S, Marasini B P, Ali Z, Devkota K P, Kengfack AE, Shaheen F, Choudhary M I, Sewald N. Xanthones inhibitors of α- glucosidase and glycation from Garcinia nobilis. Phytochem. Lett. 2012; 5 ( 2): 236–239. https://doi.org/10.1016/j.phytol.2012.01.002

Zhang H and Tsao R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Curr. Opin. Food Sci. 2016; 8: 33–42. https://doi.org/10.1016/j.cofs.2016.02.002

Pereira DF, Cazarolli LH, Lavado C, Mengatto V, Figueiredo MSRB, Guedes A, Pizzolatti MG, Silva FRMB. Effects of flavonoids on α-glucosidase activity: Potential targets for glucose homeostasis. Nutrition. 2011; 27: 1161–1167. doi: 10.1016/j.nut.2011.01.008.

Revathi P, Jeyaseelan S, Thirumalaikolundu SP, Manickavasagam S, Prabhu N. A comparative mechanism of antidiabetic role of various extracts of Bruguriera cylindrica L leaves. 2015; 4 (5): 1168–1176.

Leyama T, Gunawan-Puteri MDPT, Kawabata J. α-Glucosidase inhibitors from the bulb of Eleutherine americana. Food Chem. 2011; 128 (2): 308–311. doi: 10.1016/j.foodchem.2011.03.021.

Azuma T, Kayano S-I, Matsumura Y, Konishi Y, Tanaka Y, Kikuzaki H. Antimutagenic and α-glucosidase inhibitory effects of constituents from Kaempferia parviflora. Food Chem. 2011; 125 (2): 471–475. https://doi.org/10.1016/j.foodchem.2010.09.033

Tabopda TK, Ngoupayo J, Awoussong PK, Mitaine-Offer AC, Ali MS, Ngadjui BT, Lacaille-Dubois M-A. Triprenylated flavonoids from Dorstenia psilurus and their α-glucosidase inhibition properties. J. Nat. Prod. 2008. 71: 2068–2072. doi: 10.1021/np800509u.

Rao SA, Srinivas PV, Tiwari AK, Vanka UMS, Rao RVS, Dasari KR, Rao MJ. Isolation, characterization and chemobiological quantification of α-glucosidase enzyme inhibitory and free radical scavenging constituents from Derris scandens Benth. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2007; 855 (2): 166–172. https://doi.org/10.1016/j.jchromb.2007.04.048

Lamien CE, Meda A, Mans J, Romito M, Nacoulma OG, Viljoen GJ. Inhibition of fowlpox virus by an aqueous acetone extract from galls of Guiera senegalensis J. F. Gmel (Combretaceae). J. Ethnopharmacol. 2005; 96: 249–253. https://doi.org/10.1016/j.jep.2004.09.016

Ooi KL, Muhammad TST, Tan ML, Sulaiman SF. Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth. J. Ethnopharmacol. 2011; 135 (3): 685–695. https://doi.org/10.1016/j.jep.2011.04.001

Ye X-P, Song C-Q, Yuan P, Mao R-G. α-Glucosidase and α-Amylase Inhibitory Activity of Common Constituents from Traditional Chinese Medicine Used for Diabetes Mellitus. Chin. J. Nat. Med. 2010; 8 (5): 349–352. https://doi.org/10.1016/S1875-5364(10)60041-6

Sombié PAED, Hilou A, Coulibaly AY, Tibiri A, Kiendrebeogo M, Nacoulma OG. Brain Protective and Erythrocytes Hemolysis Inhibition Potentials. J. Pharmacol. Toxicol. 2011; 6 (4): 361–370. doi: 10.3923/jpt.2011.361.370

Aslan M, Orhan N, Orhan DD, Ergun F. Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes. J. Ethnopharmacol. 2010; 128 ( 2): 384–389. https://doi.org/10.1016/j.jep.2010.01.040

Jdir H, Khemakham B, Chakroun M, Zouari S, Ali YB, Zouari N. Diplotaxis simplex suppresses postprandial hyperglycemia in mice by inhibiting key-enzymes linked to type 2 diabetes. Rev. Bras. Farmacogn. 2015; 25 (2): 152–157. http://dx.doi.org/10.1016/j.bjp.2015.02.004

Hyun TK, Eom SH, Kim J-S. Molecular docking studies for discovery of plant- derived α -glucosidase inhibitors. Plant Omics Journal. 2014; 7 (3): 166–170.

Bi X, Soong YY, Lim SW, Henry CJ. Evaluation of antioxidant capacity of Chinese five-spice ingredients. Int. J. Food Sci. Nutr. 2015; 66 (3): 289–292. https://doi.org/10.3109/09637486.2015.1007452

Navarro M, Morales FJ. Mechanism of reactive carbonyl species trapping by hydroxytyrosol under simulated physiological conditions. Food Chem. 2015; 175: 92–99. https://doi.org/10.1016/j.foodchem.2014.11.117

Nikmaram N, Leong SY, Koubaa M, Zhu Z, Barba FJ, Greiner R, Oey I, Roohinejad S. Effect of extrusion on the anti-nutritional factors of food products: An overview. Food Control. 2017. http://dx.doi.org/10.1016/j.foodcont.2017.03.027

Adeyemo SM, Onilude AA. Enzymatic Reduction of Anti-nutritional Factors in Fermenting Soybeans by Lactobacillus plantarum Isolates from Fermenting Cereals. Niger. Food J. 2013; 31 (2): 84–90. https://doi.org/10.1016/S0189-7241(15)30080-1


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Copyright (c) 2018 Pierre Alexandre Eric Djifaby SOMBIE, Rahman M HAFIZUR, Moussa COMPAORÉ, Martin KIENDREBEOGO, Muhammad Iqbal CHOUDHARY, Odile Germaine NACOULMA

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