Evaluation of important mineral nutrients and vitamins in polyherbal medicines used for the treatment of tuberculosis in the Eastern Cape Province, South Africa

Elizabeth Bosede Famewo, Anna Maria Clarke, Anthony Jide Afolayan

DOI: http://dx.doi.org/10.5138/09750185.2139

Abstract


Polyherbal medicines are widely used for the treatment of various diseases in the developing countries. In order to validate their ability in boosting the immune system of tuberculosis patients, the mineral nutrients and vitamins present were determined. Their nutritive properties were analysed using an inductively coupled plasma optical emission spectrometer, while the vitamins were determined using standardized methods. The polyherbal preparations were found to be rich in mineral nutrients and vitamins. Calcium was the highest mineral nutrient detected, while the lowest nutrient was phosphorus. Quantitatively, calcium and magnesium contents in the remedies ranged from 973.30 to 6503.30 mg/100g and 80.00 to 406.00 mg/100g respectively. The amount of phosphorus and potassium was between 20.00 and 263.30 mg/100g; 160.00 and 2050.00 mg/100g respectively. Micro nutrients such as iron, manganese, zinc, aluminium and copper were also detected. Iron was the highest nutrient in the majority of the polyherbal preparations while the lowest value was recorded for copper. However, vitamin C was absent in the herbal preparations while vitamin A and E were detected. These findings indicate that these polyherbal formulations contain the essential mineral nutrients and vitamins that could probably be boosting the immune system of tuberculosis patients. 


Keywords


Mineral nutrients, polyherbal medicines, tuberculosis, vitamins,

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References


[1] Chakraborty S, Syal K, Bhattacharyya R, Banerjee D. Vitamin deficiency and tuberculosis: need for urgent clinical trial for management of tuberculosis. J Nutr Health Food Sci. 2014; 2(2): 1-6.

[2] World Health Organization, “Global tuberculosis report,” WHO, Geneva, 2016. http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng.pdf. Accessed 27 July 2016.

[3] Baldwin PR, Reeves AZ, Powell KR, Napier RJ, Swimm AI, Sun A, Giesler K, Bommarius B, Shinnick TM, Snyder JP, Liotta DC. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis. Euro J med Chem. 2015; 92: 693-699.

[4] TBFACTS.ORG | Information about Tuberculosis. http://www.tbfacts.org/tb-statistics South-Africa/2015. Accessed 23 May 2015.

[5] World Health Organization, “Guideline: Nutritional care and support for patients with tuberculosis.” Geneva, 2013. World Health Organization. http://apps.who.int/iris/bitstream/10665/94836/1/9789241 506410_eng.pdf?ua=1

[6] Gupta KB, Gupta R, Atreja A, Verma M, Vishvkarma S. Tuberculosis and nutrition. Lung India. 2009; 26(1): 9.

[7] Ciccone MM, Cortese F, Gesualdo M, Carbonara S, Zito A, Ricci G, De Pascalis F, Scicchitano P, Riccioni G. Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular care. Mediators of inflammation. 2013; 2013.

[8] Wahlqvist ML. Antioxidant relevance to human health. Asia Pac J Clin Nutr. 2013; 22(2): 171-176.

[9] Safarian MD, Karagezian KG, Karapetian ET, Avanesian NA. The efficacy of antioxidant therapy in patients with tuberculosis of the lungs and the correction of lipid peroxidation processes. Problemy tuberkuleza. 1989; (5): 40-44.

[10] Peltzer K. Utilization and practice of traditional/complementary/alternative medicine (TM/CAM) in South Africa. Afr J Trad Complement Alter Med. 2009; 6(2): 175.

[11] Soni HK, Ribadiya NC, Bhatt SB, Sheth NR. Evaluation of herbal formulation (capsule) containing Ashwagandha as a single herb with their nutritional value determination. Inter J Appl Biol Pharm Technol. 2010; 1: 960-967.

[12] Dickson RA, Amponsah IK, Annan K, Fleischer TC. Nutritive potential of a polyherbal preparation from some selected Ghanaian Herbs. 2014

[13] Famewo EB, Clarke AM, Afolayan AJ. Identification of bacterial contaminants in polyherbal medicines used for the treatment of tuberculosis in Amatole District of the Eastern Cape Province, South Africa, using rapid 16S rRNA technique. J Health Popul Nutr. 2016; 35(1): 27.

[14] Bvenura C, Afolayan AJ. Heavy metal contamination of vegetables cultivated in home gardens in the Eastern Cape. South African Journal of Science. 2012; 108(9- 10): 1-6.

[15] Onyesife CO, Ogugua VN, Anaduaka EG. Investigation of some important phytochemicals, vitamins and mineral constituents of ethanol leaves extract of Piper nigrum, Annals of Biol Res.2014; 5: 20-25.

[16] Njoku NE, Ubbaonu CN, Alagbaoso SO, Eluchie CN, Umelo MC. Amino acid profile and oxidizable vitamin content of Synsepalum dulcificum berry (miracle fruit) pulp. Food Sci Nutr. 2015; 3(3): 252-256.

[17] Bhope SG, Nagore DH, Kuber VV, Gupta PK, Patil MJ. Design and development of a stable polyherbal formulation based on the results of compatibility studies. Pharmacog Res. 2011; 3(2): 122.

[18] Pravina P, Sayaji D, Avinash M. Calcium and its role in human body. Inter J Res Pharm Biomed Sci. 2013; 4(2): 659-68.

[19] NHMRC National Health and Medical Research Council. Nutrient Reference Valves for Australia and New Zealand including Recommended Dietary Intakes. Department of Health and Ageing, Australian Government, Australia. 2005. <https://www.nhmrc.gov.au/_files_nhmrc/publications/attachments/n35.pdf

[20] IOM Institute of Medicine. Food and Nutrition Board. Committee to Review Intakes for vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D. Washington, D.C: National Academy Press, 2010.

[21] Young DB. Role of potassium in preventive cardiovascular medicine. Springer Science & Business Media. 2012.

[22] IOM Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Calcium Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press. 1997. <http://www.nap.edu/catalog/5776.html.

[23] Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD. Encyclopedia of Dietary Supplements. 2nd eds. New York, NY: Informa Healthcare; 2010. Pp. 527-537.

[24] Rude RK. Magnesium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR. Modern Nutrition in Health and Disease. 11th eds. Baltimore, Mass: Lippincott Williams & Wilkins; 2012. Pp. 159-175.

[25] Capra S. Nutrient reference values for Australia and New Zealand: Including recommended dietary intakes. Commonwealth of Australia; 2006.

[26] Wessling-Resnick M. Iron. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR. Modern Nutrition in Health and Disease. 11th eds. Baltimore, MD: Lippincott Williams & Wilkins. 2014; pp. 176-188.

[27] Aggett PJ. Iron. In: Jr Erdman JW, MacDonald IA, Zeisel SH, “Present knowledge in nutrition,” 10th ed. Washington, DC: Wiley-Blackwell; 2012. pp. 506-520.

[28] Murray-Kolbe LE, Beard J. Iron. In: Coates PM, Betz JM, Blackman MR et al. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010. pp. 432-438.

[29] Karyadi E, Schultink W, Nelwan RH, Gross R, Amin Z, Dolmans WM, van der Meer JW, Hautvast JG, West CE. Poor micronutrient status of active pulmonary tuberculosis patients in Indonesia. The J Nutr. 2000; 130(12): 2953-2958.

[30] IOM Institute of Medicine. Food and Nutrition Board. Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. Washington, D. C.: National Academy Press; 2001. pp. 394-419.

[31] Ramakrishnan K, Shenbagarathai R, Kavitha K, Uma A, Balasubramaniam R, Thirumalaikolundusubramanian P. Serum zinc and albumin levels in pulmonary tuberculosis patients with and without HIV. Japanese J Infect Dis. 2008; 61(3): 202.

[32] Muthuraj M, Kamatchiyammal S, Usharani B, Manupriya S, Ayyappan AN, Divyalakshmi K. Serum zinc, calcium and albumin levels in pulmonary tuberculosis patients co-Infected with HIV. Global J Biotech Biochem. 2010; 5(1): 27-35.

[33] Martini LA, Catania AS, Ferreira SR. Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus. Nutr Rev. 2010; 68(6): 341-54.

[34] Seyedrezazadeh E, Ostadrahimi A, Mahboob S, Assadi Y, Ghaemmagami J, Pourmogaddam M. Effect of vitamin E and selenium supplementation on oxidative stress status in pulmonary tuberculosis patients. Respirology. 2008; 13(2): 294-298.

[35] South African National Department of Health. South African National Guidelines on Nutrition for People Living with HIV, Aids, TB and other Chronic Debilitating Conditions. 2001.


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