Resveratrol and Quercetin: Novel Polyphenolic Chemopreventive Agents

Mohammad Younis Bhat, Samina Farhat, Sheikh Shoib, Zorawar Singh

Abstract


Cancer continues to be a major public health concern worldwide and the main modalities for treatment include chemo and/or radiotherapy and surgery which are often commonly used in conjuction to control and treat cancer. Recent advances in the area of cancer prevention have opened new avenues for research and several medicinal plants are being used to prevent and cure a variety of diseases, including oncological ailments. Herbal drugs have been in use for several thousands of years in various traditional systems of medicine existing in different parts of the world. In recent years, there has been a paradigm shift in the way we look at herbals which today are being viewed as potential agents for tackling various diseases, particularly for which there is no effective cure available in modern system of medicine or when the side effects of synthetic drugs are too many. It has been estimated by the World Health Organization (WHO) that currently 80% of the world’s population is still dependent on herbal drugs for solving their health needs in one or the other way. They are less toxic alternatives to modern medicine, offer much scope for prevention of diseases, are easily available, cheaper costs, effective nature and promise to cure the so far incurable diseases like cancer, AIDS, hepatitis C, Alzheimer’s and Parkinson’s disease, diabetes makes them much sought for. Chemoprevention offers a promising approach to primary cancer prevention for a variety of organs. A plethora of compounds, including several promising plant derived compounds are being evaluated in the laboratories and two phytocompounds which hold a lot of promise include resveratrol and quercetin – as novel chemopreventive agents.

Keywords


Resveratrol; Quercetin; Cancer; Polyphenolic; Chemopreventive Agents

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References


Sporn MB. Approaches to the prevention of epithelial cancer during the preneoplastic period. Cancer Res 1976; 36: 2699-70.

Keloff GJ, Crowell JA, Boone CW et al. Strategy and planning for chemopreventing drug development: clinical development plan. J Cell Biochem Supp 1994; 56(S20): 55-62.

Greenwald P. Cancer chemoprevention. British Medical Journal 2002; 324(7339): 714-18.

Tsao AS, Kim ES, Hong WK. Chemoprevention of cancer. CA: A Cancer Journal for Clinicians 2004; 54(3): 150-80.

Balunar MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sciences 2005; 178: 431-41.

Sogno H, Vannini N, Lorusso G et al. Anti-angiogenic activity of a novel class of chemopreventive compounds: Oleanicacid terpenoids. Recent Results Cancer Res 2009; 181: 209-12.

Alam MS, Kour G, Jabba Z et al. Evaluation of anti oxidant activity of salix capsea flowers. Phytother Res 2006; 20(6): 479-83.

Dietz BM, Kang YH, Liu G et al. Xantho-humol isolated form Humulus lupulus inhibits menadione-induced DNA damage through induction of quinine reductase. Chem Res Toxicol 2005; 18(8): 1296-305.

Wargovich MJ. Nutrition and cancer: the herbal revolution. Curr Opin Gastroenterol 1999; 15(2): 177.

Graf J. Herbal anti-inflammatory agents for skin disease. Skin Ther Lett 2000; 5: 3-5.

Neto CC. Cranberry and its pharmaceuticals: a review of in vitro anticancer studies. J Nutr 2007; 137(1 Suppl): 1865-935.

Yang CS, Landau JM, Huang MT et al. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annal Rev Nutr 2001; 21: 381-406.

Bushman JL. Green tea and cancer in humans: a review of the literature. Nutr Cancer 1998; 31: 151-59.

Aggarwal BB et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 2004; 24(5A): 2783-840.

Delmas D et al. Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets 2006; 7(4): 423-42.

Schoeppner A, Kindl H. Stilbene synthase (pinosylvine synthase) and its induction by ultraviolet light. FEBS Lett 1979; 108: 349-52.

Gehlert R, Schoppner A, Kindl H. Stilbene synthase from seedlings of pinus sylvestris: purification and induction in response to fungal infection. Mol Plant Microbiol Interactions 1990; 3: 444-49.

Wolcott GN. Stilbene and comparable materials for dry wood termite control. J Econ Enterol 1953; 46: 374-75.

Rosemann D, Heller W, Sanderman H Jr. Biochemical plant response to ozone II. Induction of stilbene biosynthesis in scots pine (pinus sylvestris L. seedings. Plant Physiol 1991; 97: 1280-86.

Pervaiz S. Resveratrol from grapevines to mammalian biology. FASEBJ 2003; 17: 1975-85.

Jemal A, Siegel R, Ward E et al. Cancer statistics. CA Cancer J Clin 2007; 57: 43-66.

Labrie F, Belonger A, Dupont A et al. Science behind total androgen blockade: from gene to combination therapy. Clinical and investigative medicine. Medicine Clinque at Experimentale 1993; 16: 475-92.

Sporn MB. Carcinogenesis and cancer: different perspectives on the same disease. Cancer Res 1991; 51: 6215-18.

Dragsted LO, Strube M, Larsen JC. Cancer protective factors in fruits and vegetables: biochemical and biological background. Pharmacol Toxicol 1993; 72 (Suppl. 1): 116-135.

Kelloff GJ, Boone CW, Crowell JA et al. Risk biomarkers and current strategies for cancer chemoprevention. J Cell Biochem Suppl. 1996; 25: 1-14.

Mitchell SH, Zhu W, Young CYE. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostrate cancer cells. Cancer Res 1999; 59: 5892-95.

Narayanan BA, Re GG, Narayanan NK. Gene expression induced by resveratrol in prostate cancer cells p53 mediated molecular targets Intent I. J Cancer 2003; 104: 204-12.

Jang M, Pezzuto JM. Effects of resveratrol on 12-O-tetradecanyrlphorbol-13-acetate-induced oxidative events and gene expression in mouse skin. Cancer Lett 1998; 134: 81-89.

Jang M, Pezuto JM. Cancer chemopreventive activity of resveratrol. Drugs Exp Clin Res 1999; 25: 65-77.

Livel A, Raanani H, Younglari E et al. Resveratrol, a natural aryl hydrocarbon receptor antagonist protects sperm from DNA damage and apoptosis caused by benzo(a) pyrene. Reprod Toxicol 2001; 15: 479-86.

Bhat KP, Lanvit D, Christov K et al. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 2001; 61: 7456-63.

She QB, Bode AM, Ma MY et al. Resveratrol induced activation of p53 and apoptosis is mediated by extracellular signal regulated protein kinases and p38 kinases. Cancer Res 2001; 61: 1604-10.

Pezutto JM. Plant derived anti cancer agents. Biochem Pharmacol 1997; 53: 121-33.

Dragsted LO. Natural antioxidants in chemoprevention. Arch Toxicol Suppl. 1998; 20: 29-36.

Steele VE, Kelloff GJ, Balentin D et al. Comparative chemopreventive mechanisms of green tea, black tea and selected polyphenol extracts measured by in vitrol bioassays. Carcinogenesis 2000; 21: 63-67.

Agarwal C, Sharma Y, Zhao J et al. A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA – MB468 cells by inhibiting mitogen-activated protein kinase activation and inducing G1 arrest and differentiation. Clin Cancer Res 2000; 6: 2921-30.

Bhat and Pezutto, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Ann NY Acad Sci 2002; 1957: 210-29.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol of resveratrol: the in vivo evidence. Nature Reviews 2006; 5: 493-506.

Fulda S, Debatin KM. Sentiziation for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 2004; 23: 6702-11.

Afaq F, Adhami VM, Ahmad N. Preventio of short term ultraviolet B radiation mediated damage by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol 2003; 180: 28-37.

Adhami VM, Afaq F, Ahmad N. Suppression of ultraviolet B exposure mediated activation of NF-kappa B in normal human keratinocytes by resveratrol. Neoplasia 2003; 5: 74-81.

Takeda K, Takemoto C, Kobayashi I et al. Ser 298 of MITF, a mutation site in waardenburg syndrome type 2, is a phosphorylation site with functional significance. Hum Mol Genet 2000; 9: 125-32.

Kleihues P, Soylemezoglu F, Schauble et al. Histopathology, classification and grading of gliomas. Glia 1995; 15: 211-21.

Jiang H, Zhang L, Kuo J et al. Resveratrol induced apoptotic death in human U25 glioma cells. Mol Cancer Ther 2005; 4: 554-67.

Fuldas, Dekatin KM. Sensitization for tumor necrosis factor related apoptosis inducing ligand – induced apoptosis by the chemo-preventive agents resveratrol. Cancer Res 2004; 64: 337-46.

Zhang W, Tei Z, Zhen HN et al. Resveratrol inhibits cell growth and induces apoptosis of rat C6 glioma cells. J Neuro Oncol 2007; 81: 231-41.

Tseng SH, Lin SM, Chen JC et al. Resveratrol suppresses the angiogenesis and tumor growth glioma in rats. Clin Cancer Res 2004; 10: 2190-202.

Huang RD, Fan Y, Hossain MZ et al. Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43. Cancer Res 1998; 58: 5089-96.

Goodenough DA, Goliger JA, Paul DL. Connexine, connexons and intracellular communicatioin. Ann Rev Biochem 1996; 65: 475-502.

Soroceanu L, Manning TJ, Sontheinu H. Reduced expression of connexn-43 and functional gap junction coupling in human gliomas. Glia 2001; 33: 107-17.

Nielson M, Ruch RJ, Vang O. Resveratrol reverses tumor promoter induced inhibition of gap-junctional inter cellular communication. Biochem Biophy Res Commun 2000; 275: 804-09.

Rempel SA, Golembicshi WA, Fisher JL et al. SPAS modulates cell growth attachment and migration of U87 glioma cells on brain extracellular matrix proteins. J Neuro Oncol 2001; 53: 149-60.

Boonstein P, Sage EH. Matricellular proteins: extracellular modulators of cell function. Curr Opin Cell Biol 2002; 14: 608-16.

Bradshaw AD, Sage EH. SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury. J Clin Invest 2001; 107: 1049-54.

Brekhen RA, Sage EH. SPARC, a matricellular protein at the cross roads of cell-matrix communication. Matrix Biol 2000; 19: 569-80.

Glembieshi WA, Ge S, Nelson K et al. Increased SPAR, expression promotes U87 glioblastoma invasion in vitro. Int J Dev Neurosci 1999; 17: 403-72.

Schultz C, Lemke N, Ge S et al. Secreted protein acidic and rich and cysteine promotes glioma invasion and delays tumor growth in vivo. Cancer Res 2002; 62: 6270-77.

Gagliano N, Moscheni C, Torri C et al. Effect of resveratrol on matrix metallo-proteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells. Biomed Pharmacother 2005; 59: 359-64.

Kuppron C, Motamed K, Sage EH et al. SPARC (BM-40 osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J Biol Chem 1998; 273: 29635-40.

Dorrie J, Geraver H, Wachter Y et al. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspace-9 in acute lymphoblastic leukemia cells. Cancer Res 2001; 61: 4731-39.

Jazirehi AR, Bonavida B. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin’s lymphoma and multiple myeloma cell lines to paclitaxel induced apoptosis. Mol Cancer Ther 2004; 3: 71-84.

Ahmad KA, Clement MV, Hanif IM et al. Resveratrol inhibits drug induced apoptosis in human leukemia cells by creating an intracellular milieu non permissive for death execution. Cancer Research 2004; 64: 1452-59.

Ahmad KA, Clement MN, Pervaiz S. Pro-oxidant activity of low doses of resveratrol inhibits hydrogen peroxide induced apoptosis. Ann NY Acad Sci 2003; 1010: 365-73.

Oh HC, Chou FP, Sheen HM et al. Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL induced cytotoxicity in endothelial cells. Clin Chim Acta 2006; 364: 196-204.

Tessitorre L, Davit A, Sarotto et al. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21CIP expression. Carcinogenesis 2000; 21: 1619-22.

Li ZG, Hong T, Shimada Y et al. Suppression of N-nitrosomethylbenzyl-amine (NMBA) induced by esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 2002; 23: 1531-36.

Banerjee S, Buero Ramos C, Aggarwal BB. Suppression of 7, 12-dimethylbenzanthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor B, cyclooxygenase 2, and matrix metalloproteinase 9. Cancer Res 2002; 62: 4945-54.

Mertens Jalcott SU, Percival SS. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Lelt 2005; 218: 141-5.

Conte A, Pellagrini S, Taghiazucchi D. Synergistic protection of PC12 cells from -amyloid toxicity by resveratrol and catechins. Brain Res Bull 2003; 6: 29-38.

Chan MM, Malliacci JA, Hwang HS et al. Synergy between ethanol and grape polyphenols, quercetin and resveratrol in the inhibitioin of the inducible nitric oxide synthase pathway. Biochem Pharmacol 2000; 60: 1539-48.

Fang JG, Lu M, Chen ZH et al. Antioxidant effects of resveratrol and its analogue against the free radical induced peroxidation of linoleic acid in micelles. Chemistry 2002; 8: 4191-98.

Baur JA, Sicnlair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews 2006; 5: 493-506.

Hakkinen SH, Karelampi SO, Heinonen IM et al. Content of the flavonols quercetin, myricetin and kaemferol in 25 edible berries. J Agric Food Chem 1999; 47: 2274-79.

Shoskes DA, Zeithlin SI, Shaked A et al. Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial. Urology 1999; 54: 960-63.

Lamson DW, Brignall MS. Antioxidants and cancer, Part 3: Quercetin. Altern Med Rev 2000; 5: 196-208.

Lee LT, Huang YT, Hwang JJ et al. Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and leteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Res 2002; 22: 1615-27.

Richter M, Ebermann R, Marian B. Quercetin induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. Nutr Cancer 1999; 34: 88-99.

Ranelletti FO, Maggiano N, Seera FG et al. Quercetin inhibits p21 – RAS expression in human colon cancer cell lines and in primary colorectal tumors. Int J Cancer 2000; 85: 438-49.

Yamashita N, Kawanishi S. Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin. Free Radic Res 2000; 33: 623-33.

Goel A, Boland CR, Chauhan DP. Specific inhibition of cycloxygenase 2 expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett 2001; 192: 111-18.

Hong J, Smith TJ, Moc T et al. Effects of purified green and black tea polyphenols on cyclo-oxygenase and lipo-oxygenase dependent metabolism of of arachidonic acid in human colon mucosa and colon tumor tissues. Biochem Pharmacol 2001; 62: 1175-83.

Hong J, Bose M, Ju J et al. Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivative effects on cytosolic phospholipase A(2); cyclooxygenases and 5-lipooxygenase. Carcinogenesis 2004; 25: 1671-79.

Ju J, Liu Y, Hong J et al. Effects of green tea and high fat diet on arachidonic acid metabolism and aberrant crypt foci formation in an azoxymethane induced colon carcinogenesis mouse model. Nutr Cancer 2003; 46: 172-78.

Ciocca DR, Clark GM, Tandon AK et al. Heat shock protein hsp 70 in patients with axillary lymphnode negative breast cancer: prognostic implications. J Natl Cancer Inst 1993; 85: 470-74.

Oesterreich S, Weng CN, Qiu M et al. The small heat shock protein HSP27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res 1993; 53: 443-48.

Hansen RK, Oesterech S, Lemieux P et al. Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells. Biochem Biophys Res Commun 1997; 239: 851-56.

Elia G, Amici G, Rossi A et al. Modulation of prostaglandin A1 induced thermotolerance by quercetin in human leukemic cells: role of heat shock protein 70. Cancer Res 1996; 56: 210-17.

Kioishi M, Hosokava N, Sato M et al. Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line. Jpn J Cancer Res 1992; 83: 1216-22.

Aalinkeel P, Bindu Kumar B, Raynolds JL et al. The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by downregulating the expression of heat shock protein 90. Prostate 2008; 68(16): 1773-89.

Deschner EE, Ruperto J, Wong G. Quercetin and rutin as inhibitors of azosymethanol induced colonic neoplasia. Carcinogenesis 1991; 12: 1193-96.

Lin SY, Tsai SJ, Wang LH et al. Protection by quercetin against cooking oil fumes – induced DNA damage in human lung adenocarcinoma CL-3 cells. Role of COX-2. Nutr Cancer 2002; 44: 95-101.

Welton AE, Hurley J, Will P. Flavonoids and arachidonic acid metabolism. Prog Clin Biol Res 1988; 280: 301-12.

Hwang D, Scallard D, Byrne J et al. Expression of cyclo-oxygenase 1 and cyclo-oxygenase 2 in human breast cancer. J Natl Cancer Inst 1998; 90: 455-60.

Tsujii ML, Kawano S, Tsuji S et al. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93: 705-16.


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