Solid Dispersions: A tool for improving the Solubility and Dissolution of Metronidazole

Sharda Sambhakar, Bishambar Singh, Kirtika Madan Madan, Monalisha Singh, Neha Kashyap, Shalini Mayle

Abstract


Metronidazole is a broad spectrum antibiotic. It is sparingly soluble in water but has oral bioavailability of 93-95%. So solid dispersions (SDs) containing metronidazole was prepared in different ratios (1:1, 1:2 and 1:5) and using different carriers like dextrose, citric acid, polyethylene glycol (PEG-4000) and polyvinylpyrrolidone (PVP). Fusion or melting method was used for SD containing dextrose and citric acid and Solvent evaporation method was used for SD containing PVP and PEG-4000. The solubility studies revealed that solubility of metronidazole was enhanced to manifolds. Best result was exhibited when drug carrier ratio is in the order of 1:5>1:2>1:1. Among the different carriers, the solubility and dissolution was increased to maximum in case of PVP and PEG and almost 100 % drug released within 1 hour. The development of solid dispersions was further confirmed by DSC and XRD.


Keywords


Metronidazole, solid dispersions, solubility enhancement, dextrose, citric acid, polyvinyl pyrrolidone and polyethylene glycols solid dispersions.

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References


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