Synthesis and in vitro drug release studies on substituted polyphosphazene conjugates of lumefantrine.

Sahil Kumar, Alka Sharma, Rajesh K Singh, DN Prasad, TR Bhardwaj

DOI: http://dx.doi.org/10.5138/09750215.2133

Abstract


The present study pertains to the delivery of antimalarial drug (Lumifantrine). In this, polyphosphazene has been used in the synthesis of polyphosphazene-linked conjugates of Lumifantrine. These polymer-linked Conjugates have been synthesized and characterized by modern analytical techniques. The in-vitro drug release of Lumifantrine drug conjugates: p-Amino benzoic acid ester substituted polyphosphazene drug conjugate (15) and Glycine methyl ester substituted polyphosphazene drug conjugate (21) have been found to be 6.00 % and 5.96% (pH 1.2), 88.52% and 79.86% (pH 7.4), respectively. These drug conjugate may prove an effective delivery system for the treatment of malaria.


Keywords


polyphosphazene, lumefantrine, conjugate, malaria, p-amino benzoic acid ester.

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Copyright (c) 2017 Sahil Kumar, Alka Sharma, Rajesh K Singh, DN Prasad, TR Bhardwaj

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