Synthesis and antimicrobial activity of N-[4-(3-Oxo-3-phenyl-propenyl)-phenyl]-2-(4-phenyl-5-pyridine-4yl-4H-[1,2,4]triazole-3-ylsulfanyl)-acetamide

Jyotindra Mahyavanshi, Maharshi Shukla, Kokila Parmar

DOI: http://dx.doi.org/10.5138/09761055.2034

Abstract


A new series of N-[4-(3-Oxo-3-phenyl-propenyl)-phenyl]-2-(4-phenyl-5-pyridine-4yl-4H-[1,2,4]triazole-3-ylsulfanyl)-acetamide have been synthesized by the claisen-schimodt condensation of N-(4-Acetyl-phenyl)-2-(4-phenyl-5-pyridin-4-yl-4H-[1,2,4]triazole-3-ylsulfanyl) and various aldehyde. The novel compounds structure has been established on the basis of their substituted aldehyde derivatives. All the compounds were characterized by FT-IR, Mass, and 1H-NMR spectroscopy. These new compounds were evaluated for their in vitro antibacterial activity and anti-fungal activity.


Keywords


Chalcone, Triazole, Antimicrobial activity

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References


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